Real-world evidence (RWE) is built on the premise that data generated during routine clinical care can reveal how medicines and interventions actually perform outside the environment of controlled trials. Electronic health records (EHRs) and disease registries are often treated as the foundational infrastructure of this approach. To improve data quality, many systems increasingly rely on… Continue reading The Hidden Architecture of RWE: When Complete Data Stop Being True Data
Category: Electronic Medical Records
The Swiss Health Data Space: Status, Progress, and Future Direction
Introduction Switzerland has been discussing digital health and data interoperability for many years, but progress has often been slow and fragmented. Health information is distributed across cantonal systems, hospitals, private practices, laboratories, insurers and research institutions, with limited coordination between them. This fragmentation affects not only continuity of care but also the ability to conduct research,… Continue reading The Swiss Health Data Space: Status, Progress, and Future Direction
European Health Data Space (EHDS): Status, Implications for Patients and Doctors
What the EHDS is and why it was established The European Health Data Space (EHDS) is a European Regulation (EU 2025/327) that entered into force in March 2025. It creates a common framework for using electronic health data across the European Union (EU). The main motivation behind the EHDS is the increasing need for… Continue reading European Health Data Space (EHDS): Status, Implications for Patients and Doctors
When the Code Isn’t Enough: Building Diagnostic Algorithms and Proxies in RWD Research
In real-world evidence (RWE) research, misclassification is a persistent methodological challenge, particularly when diagnostic information is incomplete, coded inconsistently, ambiguously recorded or entirely absent. When working with data from secondary data sources such as administrative claims or electronic health records (EHRs), not every condition of interest is captured cleanly (or at all) through a well-defined… Continue reading When the Code Isn’t Enough: Building Diagnostic Algorithms and Proxies in RWD Research
How Local Healthcare Systems Shape the Availability and Quality of Real World Data
Real-world evidence (RWE) research is deeply influenced by the way healthcare systems are structured. Local regulations, institutions, reimbursement models, and IT infrastructure all shape how real-world data (RWD) are generated, collected, stored, and made accessible. By tracing the patient’s journey through a country’s healthcare system, we can understand where data are generated, who controls them,… Continue reading How Local Healthcare Systems Shape the Availability and Quality of Real World Data