When the Real World Emerges from the Trial Shadow: Cardiovascular RWE at an Inflection Point

by Mathieu Ghadanfar, MD, FESC, FAHA     Cardiovascular medicine has entered an era of extraordinary randomized evidence. DAPA-HF, EMPEROR-Reduced, EMPA-KIDNEY, the SELECT trial (1, 2, 3): each enrolling tens of thousands of patients, each reshaping guidelines. And yet the questions that dominate daily clinical decision-making remain unanswered by any of them. No large randomized… Continue reading When the Real World Emerges from the Trial Shadow: Cardiovascular RWE at an Inflection Point