2025 -  WEEK 4 - What's New in RWE Research

 

  1. Access to child-appropriate medicines: an exploratory survey of the use of paediatric use marketing authorisation products in the UK. Wan M, Houshian A, Tomlin S, Rashed AN.Eur J Pediatr. 2025 Jan 25;184(2):154.

 

  1. Connecting electronic health records to a biomedical knowledge graph to link clinical phenotypes and molecular endotypes in atopic dermatitis. Frau F, Loustalot P, Törnqvist M, Temam N, Cupe J, Montmerle M, Augé F.Sci Rep. 2025 Jan 24;15(1):3082.

 

  1. Impact of COVID-19 vaccination on hospitalization, hospital utilization and expenditure for COVID-19: A retrospective cohort analysis of a South African private health insured population. Solanki G, Cleary S, Little F. PLoS One. 2025 Jan 24;20(1):e0317686.

 

  1. Healthcare resource utilization and costs in immunodeficient patients receiving subcutaneous Ig: Real-world evidence from France. Lefèvre G, Borget I, Lefèvre C, Maherzi C, Nucit A, Hennaoui M, Schmidt A, Lennon H, Grenier B, Daydé F, Mahlaoui N. PLoS One. 2025 Jan 24;20(1):e0313694.

 

  1. Niraparib Maintenance Therapy in Patients with Platinum-Sensitive Recurrent Ovarian Cancer: Real-World Experience at Hospitals in Spain. Rodríguez Sagrado MA, Alvarez Criado J, Arenaza Peña AE, Escudero-Vilaplana V, Folguera Olias C, Herrero Fernandez M, Martinez Nieto C, Rubio Salvador AR, Sanmartin Fenollera P, Vazquez Castillo MJ. Target Oncol. 2025 Jan 24.

 

  1. A Retrospective Analysis of the Impact of Electroconvulsive Therapy on Anxiety Symptoms in Patients With Treatment-Resistant Depression. Laszcz J, Wang C, Riva-Posse P, Kim J, Tsygankova V, Mandell A, Rice H, Hermida A, Kitay BM, Crowell A, McDonald WM, Hershenberg R. J ECT. 2025 Jan 24.

 

  1. Real-World Experience with CDK4/6 Inhibitors in the First-Line Palliative Setting for HR+/HER2- Advanced Breast Cancer. Patel R, Mathews J, Hamm C, Kulkarni S, Gupta R, Opperman T, Chiong JD, Nasser A. Curr Oncol. 2025 Jan 20;32(1):52.

 

  1. Combining SKY92 gene expression profiling and FISH (according to R2-ISS) defines ultra-high-risk Multiple Myeloma. Zhou X, Hofmann A, Engel B, Vogt C, Nerreter S, Tamamushi Y, Schmitt F, Leberzammer M, Stanojkovska E, Truger M, Xiao X, Riedhammer C, Steinhardt MJ, John M, Mersi J, Han S, Munawar U, Waldschmidt JM, Haferlach C, Einsele H, Rasche L, Kortüm KM. 2025 Jan 23;9(1):e70078.

 

  1. Improving Mental Health and Well-Being Through the Paradym App: Quantitative Study of Real-World Metaxa AM, Liverpool S, Eisenstadt M, Pollard J, Carlsson C. JMIR Form Res. 2025 Jan 23;9:e68031.

 

  1. Real-world evidence of yellow Fever vaccination data-driven study. Farnsworth MG, Khanipov K, Botnar K, Weaver SC, Barrett ADT, Golovko G. 2025 Jan 22;48:126758.

 

  1. Long-term outcome and predictors of vagus nerve stimulation for drug-resistant epilepsy: Real-world evidence from the Korean national hospital consortium. Lee SY, Lee H, Cho JW, Kang KW, Seo JG, Kim JS, Kang JW, Kim D, Kim YS, Choi SA, Park J, Phi JH, Nam SO, Kim WS, Kim JM, Kim KJ; Korean National Hospital Consortium for VNS Outcome Study. Epilepsy Res. 2025 Jan 20;210:107511.

 

  1. Comparative cardiometabolic safety and effectiveness of aripiprazole in people with severe mental illness: A target trial emulation. Richards-Belle A, Launders N, Hardoon S, Richards A, Man KKC, Davies NM, Bramon E, Hayes JF, Osborn DPJ. PLoS Med. 2025 Jan 23;22(1):e1004520.

 

  1. A Canadian real-world, multi-center, prospective, observational study assessing the treatment duration, the treatment sequence, and the overall survival for patients treated with endocrine therapy targeted therapy in HR + HER2-negative advanced breast cancer. Doyle C, Lohmann AE, Iqbal N, Henning JW, Kulkarni S, Califaretti N, Hilton J, Ferrario C, Bouganim N, Mates M, Guillemette S, Leite R, Caron MA, Thireau F, Machado A, Chia S. Breast Cancer Res Treat. 2025 Jan 23.

 

  1. Pragmatic Clinical Trials: A Study Design for Real-World Evidence. Capili B, Anastasi JK. Am J Nurs. 2025 Feb 1;125(2):56-58.

 

  1. Empowering African Expertise: Enhancing Safety Data Integration and Signal Detection for COVID-19 Vaccines Through the African Union Smart Safety Surveillance Joint Signal Management Group. Namba VP, Gunter HM, Adeyemo MB, Bhawaneedin NY, Blockman M, Sabblah GT, Gyapong JO, Guantai EM, Abebe T, Abebe W, Lawson HJ, Leburu MC, Mohammed A, Amponsa-Achiano K, Matlala MF, Elemuwa UG, Mogtari H, Nyarko AK, Schönfeldt M, Kamupira M, McCarthy K, Tefera YL, Alemu A, Yusuf KM, Emelife O, Sidibe L, Dandajena K, Onu K, Adeyeye MC, Darko DM, Gerba H, Semete B, Siyoi F, Ambali A, Meyer JC. Drug Saf. 2025 Jan 22.

 

  1. Real life outcome analysis of breast cancer brain metastases treated with Trastuzumab Deruxtecan. Fabi A, Rossi A, Caputo R, Pisegna S, Scagnoli S, Pantano F, D'Auria G, Fedele P, Fabbri A, Vernieri C, Palleschi M, Carbognin L, Ferretti G, Di Monte E, Paris I, Pavese F, Garrone O, Franco A, De Laurentiis M, Franceschini G, Scambia G, Giannarelli D, Masetti R, Botticelli A. NPJ Precis Oncol. 2025 Jan 22;9(1):22.

 

  1. Real-world clinical multi-omics analyses reveal bifurcation of ER-independent and ER-dependent drug resistance to CDK4/6 inhibitors. Kan Z, Wen J, Bonato V, Webster J, Yang W, Ivanov V, Kim KH, Roh W, Liu C, Mu XJ, Lapira-Miller J, Oyer J, VanArsdale T, Rejto PA, Bienkowska J. Nat Commun. 2025 Jan 22;16(1):932.

 

  1. Blinding assessment in randomised sham-controlled trials of acupuncture:protocol for a systematic survey. Yang J, Liu J, Luo X, Yao M, Fu Y, Li L, Sun X. BMJ Open. 2025 Jan 22;15(1):e090238.

 

  1. Nature and prevalence of long-term conditions in people with intellectual disability: retrospective longitudinal population-based study. Lewin G, Kousovista R, Abakasanga E, Shivamurthy R, Cosma G, Jun G, Kaur N, Akbari A, Gangadharan S. BMJ Open. 2025 Jan 22;15(1):e090857.

 

  1. An anonymized, de-identified registry study protocol to determine the effectiveness and safety of weight loss with enavogliflozin in patients with type 2 diabetes mellitus. Sang H, Kim S, Hwang J, Woo S, Kim J, Yon DK, Rhee SY. PLoS One. 2025 Jan 22;20(1):e0315603.

 

  1. Comparative Effectiveness of Amniotic and Chorionic Grafts in the Treatment of Lower-Extremity Diabetic Ulcers Using U.S. Medicare Real-World Evidence (2018-2022): A Retrospective Observational Cohort. Padula WV, Ramanathan S, Cohen BG, Chingcuanco F, Steel P, Herzer KR. Adv Wound Care (New Rochelle). 2025 Jan 22.

 

  1. Cumulative risk of diabetic foot complications in risk groups of type 1 and type 2 diabetes: Real-world evidence from a 22-year follow-up study. Akerkar A, Rønn PF, Kosjerina V, Hansen CS, Hulman A, Persson F, Rasmussen A, Rossing P, Ahluwalia TS. Diabetes Obes Metab. 2025 Jan 22.

 

  1. Association between adolescent obesity and early adulthood healthcare utilization-a two-cohort prospective study. Hagman E, Halsteinli V, Putri RR, Hansen Edwards C, Waaler Bjørnelv G, Marcus C, Ødegård RA. BMC Med. 2025 Jan 21;23(1):33.

 

  1. Operationalising routinely collected patient data in research to further the pursuit of social justice and health equity: a team-based scoping review. Chadd K, Caute A, Pettican A, Enderby P. BMC Med Res Methodol. 2025 Jan 21;25(1):14.

 

  1. Real-World-Evidence of Digital Health Applications (DiGAs) in Rheumatology: Insights from the DiGAReal Registry. Albrecht A, Taubmann J, Minopoulou I, Hatscher L, Kleinert S, Mühlensiepen F, Welcker M, Leipe J, Schulz N, Klemm P, Hueber A, Schett G, Kuhn S, Labinsky H, Knitza J. Rheumatol Ther. 2025 Jan 21.

 

  1. Clinical Experiences Using Family Based Treatment for Eating Disorders. Gioia AN, Morales C, Laboe AA, Dolan SC, Reilly EE. Int J Eat Disord. 2025 Jan 20.

 

  1. Slipping Through the Cracks? Concussion Management in Aotearoa New Zealand Secondary Schools. Salmon D, Badenhorst M, Zoellner A, Skilton D, Mossman K, Lucas P, Thompson K, Walters S, Keung S, Sole G. J Sch Health. 2025 Jan 20.

 

  1. Andexanet alfa in patients with factor Xa inhibitor associated intracranial hemorrhage: the prospective observational multicenter ASTRO-DE study. Diener HC, Kuklik N, Hüsing A, Alonso A, Nabavi D, Poli S, Gabriel MM, Maier I, Grans J.Int J Stroke. 2025 Jan 20:17474930251317385.

 

  1. Barriers and Facilitators of User Engagement With Digital Mental Health Interventions for People With Psychosis or Bipolar Disorder: Systematic Review and Best-Fit Framework Synthesis. Eisner E, Faulkner S, Allan S, Ball H, Di Basilio D, Nicholas J, Priyam A, Wilson P, Zhang X, Bucci S. JMIR Ment Health. 2025 Jan 20;12:e65246.

 

  1. Telehomecare Monitoring for Patients Receiving Anticancer Oral Therapy: Protocol for a Mixed Methods Evaluability Study. Tremblay D, Joly-Mischlich T, Dufour A, Battista MC, Berbiche D, Côté J, Décelles M, Forget C, Guérin B, Larivière M, Lemay F, Lemonde M, Maillet É, Moreau N, Pavic M, Soldera S, Wilhelmy C. JMIR Res Protoc. 2025 Jan 20;14:e63099.

 

  1. Feasibility and Acceptability of Smartwatches for Use by Nursing Home Residents. Johnson AH, Lee K, Reeder B, Popejoy L, Vogelsmeier A. Comput Inform Nurs. 2025 Jan 20.

 

  1. Anticipating impending peripheral intravenous catheter failure: A diagnostic accuracy observational study combining ultrasound and artificial intelligence to improve clinical care. Bahl A, Johnson S, Mielke N, Blaivas M, Blaivas L. J Vasc Access. 2025 Jan 20:11297298241307055.

 

  1. Safety and effectiveness in an uncontrolled setting of glucagon-like-peptide-1 receptor agonists in patients with familial partial lipodystrophy: Real-life experience from a national reference network. Lamothe S, Belalem I, Vantyghem MC, Nobecourt E, Mosbah H, Béliard S, Delemer B, Dupuis H, Vandenbroere P, Scheyer N, Amouyal C, Hadjadj S, Janmaat S, Vigouroux C, Vatier C. Diabetes Obes Metab. 2025 Jan 20.

 

  1. Health Care Resource Use and Costs of Rivaroxaban Versus Warfarin Among Nonvalvular Atrial Fibrillation Polypharmacy Patients With Obesity. Alberts M, He J, Kharat A, Pericone CD, Ashton V. J Am Heart Assoc. 2025 Jan 21;14(2):e036401.

 

  1. A framework for monitoring RSV prevention product effectiveness in the United States. Roper LE, Link-Gelles R, Surie D, DeCuir J, Zambrano LD, Prill MM, Havers FP, Jones JM, Melgar M, Hall AJ, Whitehead RD Jr, McMorrow ML, Ioannou GN, Hernandez-Romieu AC, Britton A, Novosad S, Martin A, Feldstein LR, Bajema KL, Kirking H, Moline H, Campbell AP, Aslan M, Hatfield K, Dawood F, Slayton R, Reddy S, Gomes D, Fleming-Dutra KE, Payne AB. 2025 Jan 25;45:126633.

 

  1. Validation of the real-world application of the Hidradenitis Suppurativa Quality of Life (HiSQOL) score to adults with hidradenitis suppurativa. Garg A, Burge R, Cohee A, Wallinger H, Truman I, Keal A, Strunk A, Barlow S. Br J Dermatol. 2025 Jan 24;192(2):261-268.

 

 

REVIEWS and META-ANALYSIS

 

  1. An evaluation of mepolizumab as an add-on maintenance treatment for severe eosinophilic asthma. Zhu Z, Chen X, Luo Y, Feng R, Zhou Z, Chen R. Expert Opin Biol Ther. 2025 Jan 24.

 

  1. Effect of Multimodal App-Based Interventions on Glycemic Control in Patients With Type 2 Diabetes: Systematic Review and Meta-Analysis. Bodner E, Roth L, Wiencke K, Bischoff C, Schwarz PE. J Med Internet Res. 2025 Jan 24;27:e54324.

 

  1. Comprehensive Genome Profiling for Treatment Decisions in Patients with Metastatic Tumors: Real-World Evidence Meta-Analysis and Registry Data Implementation. Zerdes I, Filis P, Fountoukidis G, El-Naggar AI, Kalofonou F, D'Alessio A, Pouptsis A, Foukakis T, Pentheroudakis G, Ahlgren J, Smith D, Valachis A. J Natl Cancer Inst. 2025 Jan 22:djaf015.

 

  1. Neurointerventional surveys between 2000 and 2023: a systematic review. Bosshart SL, Stebner A, Weyland CS, Radu RA, Ospel JM; EYMINT research and survey committee. J Neurointerv Surg. 2025 Jan 24:jnis-2024-022298.

 

  1. Machine learning algorithms for predicting PTSD: a systematic review and meta-analysis. Vali M, Nezhad HM, Kovacs L, Gandomi AH.BMC Med Inform Decis Mak. 2025 Jan 21;25(1):34.

 

  1. Increasing dosing intervals for biologics in atopic dermatitis-why, who, when and how? Jacobson ME, Boesjes CM, de Bruin-Weller MS, de Graaf M, Morimoto RY, Simpson EL.J Eur Acad Dermatol Venereol. 2025 Jan 22. Review.