2025 -  WEEK 24

What's New in RWE Research this Week

  1. Defining non-small cell lung cancer tumor microenvironment changes at primary and acquired immune checkpoint inhibitor resistance using clinical and real-world data. Lee LH, Xu X, Mourikis T, Tang F, Fairchild L, Ji L, Grauel AL, Wagner JP, Szpakowski S, Pelletier MR, Kattenhorn L, Sansregret L, Costa C, Bossen C, Burks H, Farago AF, Wu J.Cancer Res Commun. 2025 Jun 9. doi: 10.1158/2767-9764.CRC-24-0605. Online ahead of print.PMID: 40488300 Free article.

 

  1. Severity of psoriasis and its impact on patient-reported outcomes (PROs): real world evidence with brodalumab 210 mg from the LIBERO study. Augustin M, Schopf RE, Quist SR, Kalyon N, von Kiedrowski RM. J Dermatolog Treat. 2025 Dec;36(1):2500511. doi: 10.1080/09546634.2025.2500511. Epub 2025 Jun 9. PMID: 40485500

 

  1. Applying Machine Learning Techniques to Predict Drug-Related Side Effect: A Policy Brief. Toni E, Ayatollahi H. Inquiry. 2025 Jan-Dec;62:469580251335805. doi: 10.1177/00469580251335805. Epub 2025 Jun 13. PMID: 40514209

 

  1. Large Language Models in Medical Diagnostics: Scoping Review With Bibliometric Analysis. Su H, Sun Y, Li R, Zhang A, Yang Y, Xiao F, Duan Z, Chen J, Hu Q, Yang T, Xu B, Zhang Q, Zhao J, Li Y, Li H. J Med Internet Res. 2025 Jun 9;27:e72062. doi: 10.2196/72062. PMID: 40489764

 

  1. Implementing performance-based risk-sharing agreements in non-small cell lung cancer immunotherapy: a real-world data case study. Bártová A, Rumi F, Santos JV, Svobodník A, Rihova B.Health Econ Rev. 2025 Jun 9;15(1):49. doi: 10.1186/s13561-025-00646-3.PMID: 40489036 Free PMC article.

 

  1. Healthcare Utilization and Provider Workload in Collegiate Student Athletes for Acute, Overuse, Time-Loss and Non-Time-Loss Injuries. Brown CN, Bovbjerg VE, Soucy MT, Choe S, Fredericson M, Simon JE.J Athl Train. 2025 Jun 9. doi: 10.4085/1062-6050-0698.24. Online ahead of print.PMID: 40489435 Free article.

 

  1. External Validation of an AI-based Preoperative Frailty Index using Real-World Data. Bai C, Xiao F, Al-Ani M, Price CC, Manini TM, Mardini MT.J Gerontol A Biol Sci Med Sci. 2025 Jun 9:glaf119. doi: 10.1093/gerona/glaf119. Online ahead of print.PMID: 40489638

 

  1. Scaling patient safety: How National Early Warning Score 2 (NEWS2) drove systemic mortality reduction in an acute care setting. Guo Y, Zhang T, Ren Y, Dou L, Zhu X, Hou Y, Gao X.Intensive Crit Care Nurs. 2025 Jun 9;90:104108. doi: 10.1016/j.iccn.2025.104108. Online ahead of print.PMID: 40493977

 

  1. An integrated framework for universal coagulation test reference intervals: Cross-platform validation of eleven indirect algorithms and age-specific hierarchical optimization. Wu Y, Huang T, Huang H, Yu F, Liu J, Tang X, Chen L, Zhou Y, He H.Clin Chim Acta. 2025 Jun 9;576:120422. doi: 10.1016/j.cca.2025.120422. Online ahead of print.PMID: 40499770

 

  1. Answering real-world clinical questions using large language model, retrieval-augmented generation, and agentic systems. Low YS, Jackson ML, Hyde RJ, Brown RE, Sanghavi NM, Baldwin JD, Pike CW, Muralidharan J, Hui G, Alexander N, Hassan H, Nene RV, Pike M, Pokrzywa CJ, Vedak S, Yan AP, Yao DH, Zipursky AR, Dinh C, Ballentine P, Derieg DC, Polony V, Chawdry RN, Davies J, Hyde BB, Shah NH, Gombar S.Digit Health. 2025 Jun 9;11:20552076251348850. doi: 10.1177/20552076251348850. eCollection 2025 Jan-Dec.PMID: 40510193 Free PMC article.

 

  1. Weighing the evidence on costs and benefits of polygenic risk-based approaches in clinical practice: A systematic review of economic evaluations. Siena LM, Baccolini V, Riccio M, Rosso A, Migliara G, Sciurti A, Isonne C, Iera J, Pierri F, Marzuillo C, De Vito C, La Torre G, Villari P.Am J Hum Genet. 2025 Jun 9:S0002-9297(25)00193-4. doi: 10.1016/j.ajhg.2025.05.012. Online ahead of print.PMID: 40513564 Review.

 

  1. Long-Term Survivorship After Gastrectomy or Endoscopic Resection for Gastric Cancer Using Nationwide Real-World Data. Woo HT, Kang SH, Baek JY, Yoo M, Park YS, Kim N, Lee DH, Kim HH, Shin A, Suh YS.J Am Coll Surg. 2025 Jun 10. doi: 10.1097/XCS.0000000000001479. Online ahead of print.PMID: 40492628

 

  1. Real-World Harm Reduction of Metformin Plus DPP4 Inhibitors versus Metformin Plus Sulfonylureas in Older Adults: A Target Trial Emulation Using German Claims Data. Starke P, Thürmann P, Grobe T, Friede T, Mathes T.Drugs Aging. 2025 Jun 10. doi: 10.1007/s40266-025-01218-0. Online ahead of print.PMID: 40493151

 

  1. Levodopa Intestinal Gel Infusion Therapies in Advanced Parkinson's Disease: A Swedish Study on Real-World Use and Costs. Odin P, Tærud C, Samuelsson J, Sabelström E, Lagerlund J, Freilich J, Stelmaszuk MN.Neurol Ther. 2025 Jun 10. doi: 10.1007/s40120-025-00766-2. Online ahead of print.PMID: 40493346

 

  1. FRAME: Framework for Real-World Evidence Assessment to Mitigate Evidence Uncertainties for Efficacy/Effectiveness - An Evaluation of Regulatory and Health Technology Assessment Decision Making. Candore G, Martin C, Mills MJ, Suter A, Lloyd A, Chavez-Montoya D, Civitelli D, Wolf B, Bolot P, Wasem J, Soriano Gabarró M, Kanavos PG, Sculpher M.Clin Pharmacol Ther. 2025 Jun 10. doi: 10.1002/cpt.3713. Online ahead of print.PMID: 40493357

 

  1. Time series differences in coagulopathy in mechanically ventilated COVID-19 and bacterial pneumonia patients: a nationwide observational study in Japan. Hisamune R, Yamakawa K, Ushio N, Mochizuki K, Matsuoka T, Umemura Y, Hayakawa M, Mori H, Endo A, Ogura T, Hirayama A, Yasunaga H, Tagami T, Okamoto K, Takasu A.Thromb J. 2025 Jun 10;23(1):61. doi: 10.1186/s12959-025-00747-3.PMID: 40495183 Free PMC article.

 

  1. Real-world data on immune checkpoint inhibitors in advanced sarcomas across multiple European institutions. Kokkali S, Dolcan A, Boye K, Kyriazoglou A, Boukovinas I, Kalofonou F, Koumarianou A, Asimakopoulou N, Vorrias E, Tsapakidis K, Georgaki E, Boulouta A, Mavroeidis L, Harneshaug M, Theocharis S, Jones RL, Digklia A.Acta Oncol. 2025 Jun 10;64:761-768. doi: 10.2340/1651-226X.2025.43135.PMID: 40495323 Free article.

 

  1. An Implemented Real-World-Data Pipeline for Standardization of Electronic Health Records in Precision Oncology. Kreimeyer K, Barasa D, Sherief M, Shi X, Borja M, Yegnasubramanian S, Anagnostou V, Murray JC, Botsis T.AMIA Jt Summits Transl Sci Proc. 2025 Jun 10;2025:242-249. eCollection 2025.PMID: 40502240 Free PMC article.

 

  1. A Review of Real-World Evidence About the Use of Automated Insulin Delivery Systems in People with Type 1 Diabetes. Gera S, Iyer J, Meighan S, March CA, Marks BE.Endocr Pract. 2025 Jun 10:S1530-891X(25)00917-6. doi: 10.1016/j.eprac.2025.06.004. Online ahead of print.PMID: 40505729 Review.

 

  1. Equivalent healthcare resource use following either a long-acting steroid-eluting implant or repeat endoscopic surgery for chronic rhinosinusitis patients with nasal polyp recurrence: a real-world evidence Feldman BS, Nelson J, Deng X, McKenzie K, Kallman JE.Curr Med Res Opin. 2025 Jun 11:1-11. doi: 10.1080/03007995.2025.2513955. Online ahead of print.PMID: 40478176

 

  1. Nonchemotherapy drug-induced cytopenias: A cost-of-illness study using the microcosting methodology based on real-world data. Stević I, Janković SM, Petrović N, Čanak-Baltić N, Marinković V, Lakić D.Br J Clin Pharmacol. 2025 Jun 11. doi: 10.1002/bcp.70122. Online ahead of print.PMID: 40497417

 

  1. Treatment patterns and outcomes by mismatch repair/microsatellite instability status among patients with primary advanced or recurrent endometrial cancer in the United States. Chase DM, Kobayashi M, Gomez P, Lubinga SJ, Chan JK.Future Oncol. 2025 Jun 11:1-12. doi: 10.1080/14796694.2025.2516891. Online ahead of print.PMID: 40497451

 

  1. Next-Generation Sequencing-Based Testing Among Patients With Advanced or Metastatic Nonsquamous Non-Small Cell Lung Cancer in the United States: Predictive Modeling Using Machine Learning Methods. Brnabic AJM, Lipkovich I, Kadziola Z, He D, Krein PM, Hess LM.JMIR Cancer. 2025 Jun 11;11:e64399. doi: 10.2196/64399.PMID: 40497643 Free article.

 

  1. Effectiveness and Safety of Upadacitinib in Patients with Moderate-to-Severe Atopic Dermatitis and Previous Failures of Th2 Biologics: A Propensity Score-Matched Study. Barei F, Chiei-Gallo A, Narcisi A, Ingurgio RC, Malagoli P, Girolomoni G, Maurelli M, Pezzolo E, Sciarrone C, Gola M, Magliulo M, Savoia P, Esposto E, Burroni AG, Amoruso F, Bianchi VG, Mercuri SR, Satolli F, De Felici Del Giudice MB, Pella P, Pinto R, Avallone G, Gurioli C, Piraccini BM, Balato A, Di Brizzi EV, Angileri RG, Manzo Margiotta F, Romanelli M, Rossi M, Guanti MB, Lauretta G, Dastoli S, Patruno C, Napolitano M, Ortoncelli M, Ribero S, Marzano AV, Ferrucci S.Clin Exp Dermatol. 2025 Jun 11:llaf253. doi: 10.1093/ced/llaf253. Online ahead of print.PMID: 40498636

 

  1. Data Resource Profile Update: CPRD GOLD. Sanchez-Santos MT, Axson EL, Dedman D, Delmestri A.Int J Epidemiol. 2025 Jun 11;54(4):dyaf077. doi: 10.1093/ije/dyaf077.PMID: 40499193 Free PMC article.No abstract available.

 

  1. Obstetric anal sphincter injuries in spontaneous vaginal births in nulliparous pregnant individuals: a 21-year cohort study based on real-world data. K L, K F, S R.Am J Obstet Gynecol. 2025 Jun 11:S0002-9378(25)00388-6. doi: 10.1016/j.ajog.2025.06.014. Online ahead of print.PMID: 40513930

 

  1. Clinical response and remission in patients treated with dupilumab for severe asthma: Results from the nationwide Danish Severe Asthma Register. Hansen S, Håkansson KEJ, Soendergaard MB, Bjerrum AS, Schmid JM, Johansson SL, Rasmussen LM, Johnsen CR, von Bülow A, Bonnesen B, Krogh NS, Hilberg O, Dongo L, Vijdea R, Ulrik CS, Porsbjerg C.Respir Med. 2025 Jun 11:108203. doi: 10.1016/j.rmed.2025.108203. Online ahead of print.PMID: 40513967

 

  1. Low-density lipoprotein cholesterol levels and treatment intensity in secondary prevention of patients with ischaemic heart disease in the primary care setting: a real-world data registry study. Sánchez-Ruano N, Fibla-Matamoros A, Falces C, Sánchez E, Sisó-Almirall A, González-de Paz L.BJGP Open. 2025 Jun 12:BJGPO.2024.0220. doi: 10.3399/BJGPO.2024.0220. Online ahead of print.PMID: 40074282 Free article.

 

  1. Analysis of the relationship between histamine H1 receptor antagonists and broad dementia events using the FAERS, JADER, and CVAR databases. Kan J, Chen Y, Gu Q, Hu N, Qiao Y, Chen Y, Chen D, Zhang H.Expert Opin Drug Saf. 2025 Jun 12:1-12. doi: 10.1080/14740338.2025.2517232. Online ahead of print.PMID: 40501012

 

  1. Nonsteroidal Mineralocorticoid Receptor Antagonists and Cardiovascular Events in Type 2 Diabetes: A Retrospective Study. Chen YH, Fang YW, Chen MT, Liou HH, Tsai MH.Eur Heart J Cardiovasc Pharmacother. 2025 Jun 12:pvaf048. doi: 10.1093/ehjcvp/pvaf048. Online ahead of print.PMID: 40503674

 

  1. Differentiation Between Early and Severe Stages of Dementia in Claims Data Based on Diagnosis, Prescription, and Utilization Patterns. Platen M, Buchholz M, Rädke A, Gläser E, Iskandar A, van den Berg N, Hoffmann W, Michalowsky B.Neurol Ther. 2025 Jun 12. doi: 10.1007/s40120-025-00778-y. Online ahead of print.PMID: 40504345

 

  1. Sustained Effectiveness, Tolerability, and Safety of Long-Term Prophylaxis with Lanadelumab in Hereditary Angioedema: The Prospective, Phase 4, Noninterventional EMPOWER Real-World Study. Bernstein JA, Betschel SD, Busse PJ, Banerji A, Wedner HJ, Manning M, Zaragoza-Urdaz RH, Anderson J, Gagnon R, Baptist AP, Soteres D, Lumry WR, Craig T, Petroni D, Hsu FI, Nova Estepan D, Juethner S, Watt M, Khutoryansky N, Zuraw BL; EMPOWER Investigators.Adv Ther. 2025 Jun 12. doi: 10.1007/s12325-025-03226-3. Online ahead of print.PMID: 40504359

 

  1. AI-Powered Drug Classification and Indication Mapping for Pharmacoepidemiologic Studies: Prompt Development and Validation. Ogorek B, Rhoads T, Finkelman E, Rodriguez-Chavez IR.JMIR AI. 2025 Jun 12;4:e65481. doi: 10.2196/65481.PMID: 40505126 Free article.

 

  1. Safety profile of intravitreal Dexamethasone implant to manage diabetic macular edema: A systematic review of real-world studies. Querques G, Figus M, De Bernardo M, Toro MD, Gharbiya M, Gallinaro V, Strina E, Cacace V, Nicolò M. 2025 Jun 12:1-24. doi: 10.1159/000545987. Online ahead of print.PMID: 40505647

 

  1. CGM-Based Real-World Data on the Transition from Glargine U100 to U300 in Children and Adolescents with Type 1 Diabetes. Tarçın G.Horm Metab Res. 2025 Jun 12. doi: 10.1055/a-2634-8614. Online ahead of print.PMID: 40506022

 

  1. Contemporary Results of Mechanical Thrombectomy and Impact of First-Line Technique on Outcome: The INSPIRE-S Global Registry. Rodrigo-Gisbert M, Ribo M, Möhlenbruch M, Nayak S, Cognard C, Fiehler J, Defreyne L, González E, Vega P, Tsang A, Orion D, Piasecki P, Ribeiro M, Fernández-Prieto A, Gentric JC, Vila O, Elsheikh S, Barbier C, Machi P, Stockx L, Costalat V, Lylyk P, González A, Lagios K, Naggara O, Spelle L, Larrea JA, Eker OF, Lobotesis K, Rautio R, Mordasini P.AJNR Am J Neuroradiol. 2025 Jun 12:ajnr.A8848. doi: 10.3174/ajnr.A8848. Online ahead of print.PMID: 40506228

 

  1. The Use of PSMA PET/CT Improves Overall Survival in Men with Biochemically Recurrent Prostate Cancer Treated with Salvage Radiotherapy: Real-World Data from an Entire Country. Mogensen AW, Torp-Pedersen C, Nørgaard M, Petersen LJ, Moe M, Zacho HD.J Nucl Med. 2025 Jun 12:jnumed.125.269996. doi: 10.2967/jnumed.125.269996. Online ahead of print.PMID: 40506242

 

  1. Using Real Electronic Health Records in Undergraduate Education: Roundtable Discussion. Nadeem F, Azmy J, Shomali AY, Diette B, Gregory LJ, Davies AC, Wilson KC.JMIR Form Res. 2025 Jun 12;9:e60789. doi: 10.2196/60789.PMID: 40511496

 

  1. Real-world effectiveness of budesonide/glycopyrronium/formoterol fumarate metered dose inhaler on symptoms and quality of life in patients with COPD: EBISU study. Muro S, Hozawa S, Sugiura H, Yoshida Y, Makita N, Kato Y, Hirai T, Nishida K, Kawayama T.Respir Investig. 2025 Jun 12;63(5):726-733. doi: 10.1016/j.resinv.2025.05.007. Online ahead of print.PMID: 40513294

 

  1. Impact of enhanced pain knowledge on core outcomes in fibromyalgia patients with high self-reported pain education needs: a target trial emulation using the DANFIB registry. Amris K, Christensen R, Wæhrens EE, Duhn PH, Henriksen M.RMD Open. 2025 Jun 12;11(2):e005576. doi: 10.1136/rmdopen-2025-005576.PMID: 40514059

 

  1. External control arm with real world data to assess the effect of semaglutide on chronic kidney disease risk among patients with type 2 diabetes. Baser O, Lu Y.Expert Opin Pharmacother. 2025 Jun 13:1-8. doi: 10.1080/14656566.2025.2518329. Online ahead of print.PMID: 40489337

 

  1. Breaking the cycle: considerations for a life-course vaccination strategy against varicella-zoster virus. Casabona G, Bonanni P, Gabutti G, Vetter V, Duchenne M, Parikh R.Expert Rev Vaccines. 2025 Jun 13. doi: 10.1080/14760584.2025.2514527. Online ahead of print.PMID: 40511469 Review.

 

  1. Effectiveness of olutasidenib versus ivosidenib in patients with mutated isocitrate dehydrogenase 1 acute myeloid leukemia who are relapsed or refractory to venetoclax: the 2102-HEM-101 trial versus a US electronic health record-based external control arm. Lai CE, Leahy TP, Turner AJ, Thomassen A, Wang L, Sheppard AD, Cortes J.Leuk Lymphoma. 2025 Jun 13:1-12. doi: 10.1080/10428194.2025.2514894. Online ahead of print.PMID: 40511494

 

  1. Quality in qualitative evidence: new best practice principles from NICE's real-world evidence Gupta VA, Scott S, Tonkinson M, Jonsson P, Goodburn L, Duffield S.J Comp Eff Res. 2025 Jun 13:e250064. doi: 10.57264/cer-2025-0064. Online ahead of print.PMID: 40511737 No abstract available.

 

  1. Treatment patterns and blood count control in 10,112 patients with polycythemia vera. Pemmaraju N, Yu J, Vasudevan A, Qureshi H, Braunstein E, Chojecki A.Expert Rev Hematol. 2025 Jun 13. doi: 10.1080/17474086.2025.2520316. Online ahead of print.PMID: 40512071

 

  1. Efficacy and safety of Glofitamab in patients with R/R DLBCL in real life setting- a retrospective study. Gurion R, Guz D, Kedmi M, Perry C, Avivi I, Horowitz NA, Abadi U, Gafter-Gvili A, Raanani P, Goldschmidt N, Nachmias B, Aumann S.Ann Hematol. 2025 Jun 13. doi: 10.1007/s00277-025-06438-3. Online ahead of print.PMID: 40512187

 

  1. Avelumab maintenance in advanced urothelial carcinoma: real-world data from Northern Spain (AVEBLADDER study). Sotelo M, Pelaez M, Basterretxea L, Varga E, Sánchez-Escribano R, Pujol Obis E, Santander C, Martínez Kareaga M, Arruti Ibarbia M, Rodríguez Ledesma I, Álvarez Fernández C, Piedra P, Calderero Aragón V, Lainez N, Verdún Aguilar JA, Gil Arnáiz I, Fernández R, Mazas C, Duran I.Clin Transl Oncol. 2025 Jun 13. doi: 10.1007/s12094-025-03950-w. Online ahead of print.PMID: 40514610

 

  1. Predictive risk factors of recurrence in breast cancer after neoadjuvant treatment: the NEORISK study. Antonio F, Carbognin L, Paris I, Di Leone A, Orlandi A, Marazzi F, Mule A, Belli P, Rossi A, Magno S, Palazzo A, Masiello V, Santoro A, Fuso P, Bria E, D'Archi S, Scardina L, Sanchez AM, Giannarelli D, Paternello S, Garganese G, Scambia G, Tortora G, Masetti R, Franceschini G, Fabi A.Future Oncol. 2025 Jun 14:1-9. doi: 10.1080/14796694.2025.2516410. Online ahead of print.PMID: 40515524

 

  1. Comparative evaluation of behavioral epidemic models using COVID-19 data. Gozzi N, Perra N, Vespignani A.Proc Natl Acad Sci U S A. 2025 Jun 17;122(24):e2421993122. doi: 10.1073/pnas.2421993122. Epub 2025 Jun 12.PMID: 40504146

 

  1. Real-world effectiveness of cariprazine in major depressive disorder and bipolar I disorder in the United States. McIntyre RS, Parikh M, Ta J, Waraich S, Cohen-Stavi C, Marci C, Nabulsi N.J Med Econ. 2025 Dec;28(1):885-898. doi: 10.1080/13696998.2025.2513766. Epub 2025 Jun 10.PMID: 40445745 Free article.

 

  1. Economic impact of in-office pediatric tympanostomy tube placement using a tympanostomy tube delivery device in a commercially- and Medicaid-insured US population. Moynihan M, Ross R, Delgado J, Gerber M, Liu G.J Med Econ. 2025 Dec;28(1):899-909. doi: 10.1080/13696998.2025.2514925. Epub 2025 Jun 10.PMID: 40478175 Free article.