2025 -  WEEK 23

What's New in RWE Research this Week

  1. Machine Learning Prediction and Validation of Plasma Concentration-Time Profiles. Iwata H, Kageyama M, Handa K.Mol Pharm. 2025 Jun 2;22(6):2976-2984. doi: 10.1021/acs.molpharmaceut.4c01431. Epub 2025 May 9.PMID: 40345671 Free PMC article.

 

  1. Should CDK4/6 inhibitors replace chemotherapy in HR+ /HER2- metastatic breast cancer with visceral crisis? Evaluating the emerging evidence. Orlandi A.Discov Oncol. 2025 Jun 2;16(1):982. doi: 10.1007/s12672-025-02699-6.PMID: 40451913 Free PMC article.

 

  1. Assessing availability of depression severity indicators in electronic health record data: A retrospective study in two large academic health care systems in the United States. Anderson HD, Kim K, Zhang M, Gutierrez E, Malhotra J, Tak C.Psychol Serv. 2025 Jun 2. doi: 10.1037/ser0000969. Online ahead of print.PMID: 40455496

 

  1. Short Research Article: Independent association between household income and family adversity and bipolar disorder in adolescence and young adulthood - a registry-data study in the Basque Country. Mar-Barrutia L, Larrañaga I, Chart-Pascual JP, Zorrilla I, Abejas-Diez D, Gomez-Prieto A, Mar J, Gonzalez-Pinto A.Child Adolesc Ment Health. 2025 Jun 2. doi: 10.1111/camh.12780. Online ahead of print.PMID: 40456264

 

  1. Population pharmacokinetics and pharmacogenomics of edoxaban in Japanese adults with atrial fibrillation. Ueshima S, Hira D, Matsuda S, Michihata R, Tabuchi Y, Ozawa T, Itoh H, Iguchi M, Akao M, Aizawa T, Kashiwa A, Shizuta S, Makiyama T, Nakagawa Y, Horie M, Terada T, Katsura T.J Pharm Health Care Sci. 2025 Jun 2;11(1):46. doi: 10.1186/s40780-025-00453-2.PMID: 40457359 Free PMC article.

 

  1. Quad Shot-A Tertiary Hospital Experience With a Palliative Radiotherapy Regimen for Head and Neck Cancer. Nikolaidou E, Bostel T, Mayer A, Wollschläger D, Schmidberger H, Kaufmann J.Head Neck. 2025 Jun 2. doi: 10.1002/hed.28202. Online ahead of print.PMID: 40457636

 

  1. Optimizing Patient Registries for Regulatory Decision Making - Key Learnings From an HMA/EMA Multistakeholder Workshop. Plueschke K, Jonker C, Kankanen H, Vetter T, Sepodes B, Naehrlich L, Hillert J, Crane G, Straus S, Foggi P, Martin S, Kyriakopoulou C, Mol P, Day F, Breen K, Bennett N, de Lemus Belmonte M, Bennett S, Verpillat P, Roes KCB, Cochino A, Schaefer F, Hernández-Rivas JM, McGettigan P, Arlett P.Clin Pharmacol Ther. 2025 Jun 2. doi: 10.1002/cpt.3733. Online ahead of print.PMID: 40457718 Review.

 

  1. Transitioning from Cangrelor to Oral P2Y12 Inhibitors in Patients with ACS: Insights from the ARCANGELO Study. De Luca L, Calabrò P, Capranzano P, Nicolini E, Mauro C, Trani C, Versaci F, Tomai F, Mattesini A, Pepe M, Berti S, Cernetti C, Musumeci G, Cirillo P.Curr Vasc Pharmacol. 2025 Jun 2. doi: 10.2174/0115701611309982250522065849. Online ahead of print.PMID: 40457976

 

  1. Prevalence of oral human papILLOmavirus infection among adult men and women in Taiwan (PILLOT). Hsu YC, Leu YS, Wang LF, Kang BH, Wang CC, Chen KT, Hsieh TC, Wu YH, Isaya S, Lou PJ.Oral Oncol. 2025 Jun 2;167:107407. doi: 10.1016/j.oraloncology.2025.107407. Online ahead of print.PMID: 40460605

 

  1. Long-term outcomes in people with CF lacking FEV1response to elexacaftor/tezacaftor/ivacaftor therapy. Hadhud M, Halevy D, Reiter J, Meir EB, Gileles-Hillel A, Sadras I, Kerem E, Cohen-Cymberknoh M, Breuer O.J Cyst Fibros. 2025 Jun 2:S1569-1993(25)01486-9. doi: 10.1016/j.jcf.2025.05.005. Online ahead of print.PMID: 40461393

 

  1. Association between SSRI use and cardiovascular outcomes in patients with coronary artery disease and generalized anxiety disorder: A real-world cohort study. Wu JY, Chang HY, Kao CL, Hung KC, Yu T, Lin YM. 2025 Jun 2;407:120390. doi: 10.1016/j.atherosclerosis.2025.120390. Online ahead of print.PMID: 40466339

 

  1. Emulations of oncology trials using real-world data: a systematic literature review. Rider JR, Wasserman A, Slipski L, Carrigan G, Harvey R, Jiao X, McRoy L, Pace ND, Becnel L, Bruno A, Eckert JC, Hodgkins P, Jain P, Merola D, Ovbiosa OE, Natanzon Y, Pinheiro S, Quinn J, Rodriguez-Watson C, Campbell U; Coalition to Advance RWE in RCT Emulations (CARE) Initiative.Am J Epidemiol. 2025 Jun 3;194(6):1783-1793. doi: 10.1093/aje/kwae346.PMID: 39252558

 

  1. Quantifying the relative intensity of free-living physical activity: differences across age, association with mortality and clinical interpretation-an observational study. Rowlands AV, Orme MW, Maylor BD, Kingsnorth AP, Henson J, Goldney J, Davies M, Razieh C, Khunti K, Zaccardi F, Yates T.Br J Sports Med. 2025 Jun 3;59(12):830-838. doi: 10.1136/bjsports-2024-108792.PMID: 39978838

 

  1. Long-term follow-up of autologous hematopoietic cell transplantation for diffuse large B cell lymphoma in the rituximab era: real-world data from a retrospective single-center analysis. Li J, Zhao F, Qian L, Yin J, Yang Y, Bai J, Zhang C, Wang T, Feng R, Liu H.Ann Hematol. 2025 Jun 3. doi: 10.1007/s00277-025-06430-x. Online ahead of print.PMID: 40457052

 

  1. Real‑World Experience of 1 Year of Tralokinumab Treatment in Adult Patients with Atopic Dermatitis: A Single-Center Retrospective Study. Rodriguez AO, Smith CS.Dermatol Ther (Heidelb). 2025 Jun 3. doi: 10.1007/s13555-025-01445-8. Online ahead of print.PMID: 40459712

 

  1. A Comprehensive Drift-Adaptive Framework for Sustaining Model Performance in COVID-19 Detection From Dynamic Cough Audio Data: Model Development and Validation. Ganitidis T, Athanasiou M, Mitsis K, Zarkogianni K, Nikita KS.J Med Internet Res. 2025 Jun 3;27:e66919. doi: 10.2196/66919.PMID: 40459919 Free article.

 

  1. Machine Learning Modeling for Predicting Infliximab Pharmacokinetics in Pediatric and Young Adult Patients With Crohn Disease: Leveraging Ensemble Modeling With Synthetic and Real-World Data. Irie K, Minar P, Reifenberg J, Boyle BM, Noe JD, Hyams JS, Mizuno T.Ther Drug Monit. 2025 Jun 3. doi: 10.1097/FTD.0000000000001348. Online ahead of print.PMID: 40459932

 

  1. Real-world treatment outcomes and clinicopathologic and molecular determinants of response to first-line lenvatinib in patients with advanced follicular cell-derived thyroid cancer. Ruicci KM, Deng Y, Xiao T, Eskander A, Goldstein D, Mete O, Mesci A, Lukovic J, Krzyzanowska MK, Barron CC, Ma LX.BJC Rep. 2025 Jun 3;3(1):41. doi: 10.1038/s44276-025-00153-2.PMID: 40461800 Free PMC article.

 

  1. Physicians' perspectives, needs, and expectations of pharmacy preoperative evaluation clinic: a qualitative study in China. Han J, Shen Z, Dou J, Lu H, Pan J, Zhu Z.BMC Health Serv Res. 2025 Jun 3;25(1):791. doi: 10.1186/s12913-025-12959-4.PMID: 40462030 Free PMC article.

 

  1. Patterns of Care Following Procedural Intervention Among Women With Overactive Bladder. Jefferson FA, Hanson KT, Khan AA, Gebhart JB, Elliott DS, Linder BJ.Neurourol Urodyn. 2025 Jun 3. doi: 10.1002/nau.70088. Online ahead of print.PMID: 40462581

 

  1. Simple vs. Complex Gastroschisis Outcomes: 30-Year Multicenter Review. Giron A, Yu PT, Schomberg J, Aziz H, Flyer Z, Awan S, Ahmad H, Goodman LF.J Pediatr Surg. 2025 Jun 3:162398. doi: 10.1016/j.jpedsurg.2025.162398. Online ahead of print.PMID: 40472889

 

  1. Real-world pharmacotherapy treatment patterns among patients diagnosed with postpartum depression in the United States. Miller DC, Chawla D, Johansen Taber K, Payne JL, Del Tredici AL.BMC Psychiatry. 2025 Jun 4;25(1):572. doi: 10.1186/s12888-025-06977-z.PMID: 40462046 Free PMC article.

 

  1. Performance Evaluation of the 2020 European Society of Cardiology 0-hr/1-hr Algorithm Using High-sensitivity Cardiac Troponin I for Non-ST-segment Elevation Acute Coronary Syndrome and Mortality Assessment Based on 1-yr Real-world Data. Ha C, Lee YJ, Seo JD, Kim H, Moon HW, Hur M, Lee YH, Park SO, Lee KR, Kim HJ, Yun YM.Ann Lab Med. 2025 Jun 4. doi: 10.3343/alm.2025.0017. Online ahead of print.PMID: 40462208 Free article.

 

  1. The duration of prior anti-tumor necrosis factor agents is associated with the effectiveness of vedolizumab in patients with ulcerative colitis: a real-world multicenter retrospective study. Kobayashi T, Hisamatsu T, Motoya S, Matsuura M, Fujii T, Kunisaki R, Shibuya T, Takeuchi K, Hiraoka S, Yasuda H, Yokoyama K, Takatsu N, Maemoto A, Tahara T, Tominaga K, Shimada M, Kuno N, Cavaliere M, Ishiguro K, Fernandez JL, Hibi T.Intest Res. 2025 Jun 4. doi: 10.5217/ir.2024.00126. Online ahead of print.PMID: 40462299 Free article.

 

  1. Use of Data Mining in the Establishment of Reference Intervals for Albumin-Adjusted Calcium. Paydaş Hataysal E, İşman FK.Clin Endocrinol (Oxf). 2025 Jun 4. doi: 10.1111/cen.15289. Online ahead of print.PMID: 40464109

 

  1. Real-World Data on Risk Factors for Emergency Department Visits to Treat Outpatient Chemotherapy Associated Toxicities. Karovic S, Dvergsten E, Pierattini C, Barac A, Fay L, Cannon TL, Harnden KK, Aragon-Ching JB, Cuevo RS, Maitland ML, Deeken JF.Cancer Res Commun. 2025 Jun 4. doi: 10.1158/2767-9764.CRC-24-0631. Online ahead of print.PMID: 40464592 Free article.

 

  1. Early Anatomical and Functional Outcomes of Faricimab in Recalcitrant Neovascular Age-Related Macular Degeneration: A Retrospective Real-World Study in an East-Asian Population. Lai YA, Tsui MC, Cheng SF, Hsieh YT, Lai TT, Hsia Y, Wang SW, Ma IH, Hung KC, Lin CP, Yang CH, Yang CM, Ho TC.Ophthalmol Ther. 2025 Jun 4. doi: 10.1007/s40123-025-01163-6. Online ahead of print.PMID: 40465138

 

  1. In-hospital mortality outcomes of favipiravir in patients with moderate to severe COVID-19 infection: An emulated target trial using real-world data from the largest field hospital in Thailand. Lumkul L, Tanasombatkul K, Nitikaroon P, Morasert T, Phinyo P.PLoS One. 2025 Jun 4;20(6):e0324903. doi: 10.1371/journal.pone.0324903. eCollection 2025.PMID: 40465794 Free article.

 

  1. Development and validation of dynamic clinical subphenotypes in acute pancreatitis patients using vital sign trajectories in intensive care units: a multinational cohort study. Wang Z, Wang W, Xu J, He Q, Sun C, Xie S, Zou K, Xia Q, Sun X.Signal Transduct Target Ther. 2025 Jun 4;10(1):180. doi: 10.1038/s41392-025-02261-4.PMID: 40467599 Free PMC article.

 

  1. Real-World Evidence in FDA Approvals for Labeling Expansion of Small Molecules and Biologics. Deng YF, Girman CJ, Ritchey ME.Ther Innov Regul Sci. 2025 Jun 4. doi: 10.1007/s43441-025-00816-9. Online ahead of print.PMID: 40468096 Review.

 

  1. Safety profile of lanreotide: a retrospective post-marketing pharmacovigilance study based on the real-world data from FAERS database. Li Y, Han Y, Gao P. 2025 Jun 4. doi: 10.1007/s12020-025-04301-z. Online ahead of print.PMID: 40468101

 

  1. Real-world survival outcomes and MDM2 prevalence in US patients with metastatic dedifferentiated liposarcoma. Robinson S, Klein AB, Stanhope SA, Evans K, Agulnik M.Future Oncol. 2025 Jun 4:1-11. doi: 10.1080/14796694.2025.2502319. Online ahead of print.PMID: 40468683

 

  1. Optimal Thromboembolism Prevention for Patients With Atrial Fibrillation on Long-Term Dialysis. Hashimoto K, Fujisaki T, Aikawa T, Iwagami M, Miyamoto Y, Slipczuk L, Biase LD, Briasoulis A, Yasuhara J, Takagi H, Kuno T.Pacing Clin Electrophysiol. 2025 Jun 4. doi: 10.1111/pace.15208. Online ahead of print.PMID: 40468697 Review.

 

  1. COVID-19 vaccine safety studies among special populations: A systematic review and meta-analysis of 120 observational studies and randomized clinical trials. Mohammadi S, Sisay MM, Saraswati PW, Osman AK, Zuithoff NPA, Weibel D, Sturkenboom M, Ahmadizar F. 2025 Jun 4;61:127342. doi: 10.1016/j.vaccine.2025.127342. Online ahead of print.PMID: 40472669 Review.

 

  1. Use of the temporary glycemic target feature in the medtronic MiniMed 780G advanced hybrid closed loop system: a real-world evidence Basset-Sagarminaga J, van den Heuvel T, Castañeda J, Cohen O.Acta Diabetol. 2025 Jun 5. doi: 10.1007/s00592-025-02526-y. Online ahead of print.PMID: 40471300

 

  1. Ixazomib-lenalidomid-dexamethasone (IRd) in relapsed refractory multiple myeloma (RRMM)-multicenter real-world analysis from Germany and comparative review of the literature. Löffler H, Braun M, Reinhardt H, Rösner A, Ihorst G, Räder J, Wenger S, Brioli A, von Lilienfeld-Toal M, Klaiber-Hakimi M, Fehr EM, Munder M, Epp K, Trautmann-Grill K, Decker S, Hoff H, Wäsch R, Engelhardt M.Ann Hematol. 2025 Jun 5. doi: 10.1007/s00277-025-06441-8. Online ahead of print.PMID: 40471328

 

  1. Outcomes Following Second Allogeneic Stem Cell Transplant for Graft Failure or Poor Graft Function: A Single Centre Experience. Kim JL, Joe MAB, Chung S, Cherniawsky H, Forrest DL, Kuchenbauer F, Lad D, Nantel SH, Narayanan S, Nevill TJ, Rodrigo J, Sanford D, Song KW, Stubbins RJ, Toze CL, White J, Abou Mourad Y, Roy C.Stem Cell Rev Rep. 2025 Jun 5. doi: 10.1007/s12015-025-10903-x. Online ahead of print.PMID: 40471438

 

  1. Real-World Data to Advance Glomerular Disease Care. Freeman NS, Bomback AS.J Am Soc Nephrol. 2025 Jun 5. doi: 10.1681/ASN.0000000758. Online ahead of print.PMID: 40471687 No abstract available.

 

  1. Potential of cenobamate as a broad-spectrum antiseizure medication. Melnick SM, Misra SN, Kamin M, Ferrari L, Glenn KJ.Expert Opin Pharmacother. 2025 Jun 5. doi: 10.1080/14656566.2025.2517352. Online ahead of print.PMID: 40472145 Review.

 

  1. Leveraging Synthetic Data to Facilitate Research: A Collaborative Model for Analyzing Sensitive National Cancer Registry Data in England. Kafatos G, Levy J, Jose S, Hindocha P, Archangelidi O, Vernon S, Frayling L.Ther Innov Regul Sci. 2025 Jun 5. doi: 10.1007/s43441-025-00820-z. Online ahead of print.PMID: 40474047

 

  1. Glucocorticoid treatment in early rheumatoid arthritis is independently associated with increased PCSK9 levels: data from a randomised controlled trial. Lend K, Twisk JW, Kumar N, Dijkshoorn B, Lampa J, Rudin A, Hetland ML, Uhlig T, Nordström D, Østergaard M, Gudbjornsson B, Sokka-Isler T, Grondal G, Hørslev-Petersen K, Nurmohamed MT, Frostegård J, van Vollenhoven RF.RMD Open. 2025 Jun 5;11(2):e005129. doi: 10.1136/rmdopen-2024-005129.PMID: 40480650 Clinical Trial.

 

  1. Long-term effectiveness of SGLT2 inhibitors in type 2 diabetes patients with myocardial injury: A population-based study. Ponzoni M, Rea F, Corrao G, Barron DJ, Cantarutti A, Morabito G.Heart Lung. 2025 Jun 5:S0147-9563(25)00129-3. doi: 10.1016/j.hrtlng.2025.05.020. Online ahead of print.PMID: 40480859

 

  1. Enzyme replacement therapies in adults with Pompe disease: from trials to real-world data. van der Beek NAME, Potters LH, Schoser B.Curr Opin Neurol. 2025 Jun 6. doi: 10.1097/WCO.0000000000001385. Online ahead of print.PMID: 40471681

 

  1. Ruxolitinib treatment outcomes in acute graft-versus-host disease (aGvHD) in a real-world setting in Finland. Martelin E, Kuikka A, Rajala H, Ruohonen T, Mönkkönen H, Vikkula J, Uusi-Rauva K, Salmenniemi U, Itälä-Remes M.Ann Hematol. 2025 Jun 6. doi: 10.1007/s00277-025-06439-2. Online ahead of print.PMID: 40473960 No abstract available.

 

  1. The use of simulations to study the effect of acquisition schemes and quantification methods using positron emission tomography: an 18F-Fallypride study. Mohlapholi MS, Doruyter A, Mix M, Trauernicht C, Ellmann A, Warwick J, Dupont P.Nucl Med Commun. 2025 Jun 6. doi: 10.1097/MNM.0000000000001995. Online ahead of print.PMID: 40474675

 

  1. Economic impact of in-office pediatric tympanostomy tube placement using a tympanostomy tube delivery device in a commercially- and Medicaid-insured US population. Moynihan M, Ross R, Delgado J, Gerber M, Liu G.J Med Econ. 2025 Jun 6:1-15. doi: 10.1080/13696998.2025.2514925. Online ahead of print.PMID: 40478175

 

  1. Equivalent healthcare resource use following either a long-acting steroid-eluting implant or repeat endoscopic surgery for chronic rhinosinusitis patients with nasal polyp recurrence: a real-world evidence Feldman BS, Nelson J, Deng X, McKenzie K, Kallman JE.Curr Med Res Opin. 2025 Jun 6:1-17. doi: 10.1080/03007995.2025.2513955. Online ahead of print.PMID: 40478176

 

  1. Drug Utilization, Adherence and Predictors of Drug-Changes and Discontinuation of Glaucoma Drug Therapies. Novella A, Quaranta L, Pasina L, Galbussera AA, Tettamanti M, Fortino I, Leoni O, Weinreb RN, Nobili A.Adv Ther. 2025 Jun 6. doi: 10.1007/s12325-025-03247-y. Online ahead of print.PMID: 40478378

 

  1. Real-World Characteristics and Treatment Patterns of Patients With Transthyretin Amyloid Cardiomyopathy: Protocol for a Multicountry Disease Registry Study. Lin YH, Chou HW, Tsai S, Gomez R.JMIR Res Protoc. 2025 Jun 6;14:e71314. doi: 10.2196/71314.PMID: 40479720

 

  1. Clinical Outcomes of Eravacycline in Patients Treated for Stenotrophomonas maltophilia Infections. Al Musawa M, Kunz Coyne AJ, Alosaimy S, Lucas K, Schrack MR, Andrade J, Herbin SR, Biagi M, Pierce M, Molina KC, Perkins NB 3rd, Cosimi R, Kang-Birken L, King MA, Pullinger BM, Rojas LM, Bouchard J, Hobbs ALV, Agee J, Caniff KE, Van Helden SR, Veve MP, Rybak MJ.Infect Dis Ther. 2025 Jun 6. doi: 10.1007/s40121-025-01170-x. Online ahead of print.PMID: 40481374

 

  1. Health-related quality of life and productivity burden for non-professional caregivers of adults with rare diseases: a real-world study. Johnson B, Gibson G, Baskerville D, Castellano G, de Courcy J, Iqbal H, Piercy J, Williams A, Pinedo-Villanueva R, Rylands A.Orphanet J Rare Dis. 2025 Jun 6;20(1):282. doi: 10.1186/s13023-025-03796-z.PMID: 40481583

 

  1. Trends in co-administration of adult vaccinations in the US retail pharmacy setting. Agrawal N, Yehoshua A, Vietri JT, Hu T, Pond T, Tort MJ, Yang J, Welch V, Boikos C, Deng S, Zheng H, Goswami A, Sharma M, Sato R.Expert Rev Vaccines. 2025 Dec;24(1):470-478. doi: 10.1080/14760584.2025.2514517. Epub 2025 Jun 5.PMID: 40455419 Free article.

 

  1. Luspatercept for the treatment of lower-risk myelodysplastic syndrome with SF3B1 mutation: a real-world single-center research in China. Liang W, Kang R, Zhao Y, Xing L, Zhang B, Shi Y, Li Y, Peng G, Zhao X, Liu X, Hu J, Hu X, Zhou K, Yang Y, Xiong Y, Li J, Fan H, Yang W, Ye L, Jing L, Zhang L, Zhang F. 2025 Dec;30(1):2506858. doi: 10.1080/16078454.2025.2506858. Epub 2025 Jun 5.PMID: 40474348