2025 -  WEEK 21

What's New in RWE Research this Week

  1. A Multicenter Real-Life Evaluation of Safety and Effectiveness of the Antibody-Drug Conjugate Sacituzumab Govitecan in Metastatic Triple-Negative Breast Cancer. Martorana F, Sanò MV, Fabi A, Paris I, Leonardi V, Bini G, Maiorana O, Vigneri P, Gebbia V, Scandurra G, Giotta F, Curaba A, Valerio MR.Am J Clin Oncol. 2025 May 19. doi: 10.1097/COC.0000000000001201. Online ahead of print.PMID: 40387297

 

  1. Real-world evidence of febrile neutropenia-related hospitalization on patients with perioperative chemotherapy for early breast cancer in Japan. Yoshinami T, Shibata N, Tamaki K, Ishimaru K, Ito S, Nukada T, Ohno S.Breast Cancer. 2025 May 19. doi: 10.1007/s12282-025-01714-6. Online ahead of print.PMID: 40388078

 

  1. Macitentan and Tadalafil Combination Therapy in Patients with Pulmonary Arterial Hypertension and Cardiovascular Comorbidities: Real-World Evidence from OPUS and OrPHeUS. Kim NH, Chin KM, McLaughlin VV, Ong R, MacDonald G, Martin N, Senatore A, Channick R.Adv Ther. 2025 May 19. doi: 10.1007/s12325-025-03180-0. Online ahead of print.PMID: 40388087

 

  1. Direct Oral Anticoagulants vs Standard Therapy in Upper Extremity Deep Vein Thrombosis: Real-World Evidence. Ruiz-Artacho P, Lecumberri R, Trujillo Santos J, Beddar Chaib F, Moustafa F, Lorenzo A, Gómez-Cuervo C, Bosevski M, Monreal M.Thromb Haemost. 2025 May 19. doi: 10.1055/a-2615-4513. Online ahead of print.PMID: 40389231

 

  1. Geographic and Racial Variation in Outcomes of Acute Venous Thromboembolism: Insights from the RIETE Registry. Tafur A, Brenner B, Demelo-Rodriguez P, Guirado Torrecillas L, Pedrajas JM, Mazzolai L, Montenegro AC, Tirado R, Villalobos-Sánchez A, Monreal M.Thromb Haemost. 2025 May 19. doi: 10.1055/a-2615-4591. Online ahead of print.PMID: 40389232

 

  1. GIANT: a prospective, multicenter, real-world study on the effectiveness, safety, and tolerability of atogepant in migraine patients with multiple therapeutic failures. Barbanti P, Egeo G, Pistoia F, Aurilia C, Scatena P, Rinalduzzi S, Strumia S, Salerno A, Frediani F, Galli A, Autunno M, Di Clemente L, Zucco M, Albanese M, Bono F, Bruno P, Borrello L, Messina S, Doretti A, Ranieri A, Camarda C, Vecchio R, Drago V, Fiorentini G, Tomino C, Bonassi S, Torelli P, Mannocci A; Italian Migraine Registry (I-GRAINE) study group.J Headache Pain. 2025 May 19;26(1):122. doi: 10.1186/s10194-025-02068-2.PMID: 40389834 Free PMC article.

 

  1. Hidradenitis Suppurativa and Ocular Diseases: Real-world Evidence of 57,972 Patients. Von Stebut-Marx J, Preissner R, Schneider-Burrus S, Preissner S.Acta Derm Venereol. 2025 May 19;105:adv42716. doi: 10.2340/actadv.v105.42716.PMID: 40390258 Free article.

 

  1. The impact of insulin pump therapy compared to multiple daily injections on complications and mortality in type 1 diabetes: A real-world retrospective cohort study. Haughton S, Riley D, Berry S, Arshad MF, Eleftheriadou A, Anson M, Yap YW, Cuthbertson DJ, Malik RA, Azmi S, Alam U, Iqbal A.Diabetes Obes Metab. 2025 May 19. doi: 10.1111/dom.16455. Online ahead of print.PMID: 40390300

 

  1. Analysis of therapeutic adherence to antidepressants and associated factors in patients with depressive disorder: A population-based cohort study. Infante-Ventura D, Rodríguez-Díaz B, García Bello MÁ, Valcárcel-Nazco C, Estupiñán-Romero F, Acosta Artiles FJ, González de León B, Hurtado-Navarro I, Del Pino-Sedeño T.J Affect Disord. 2025 May 19;385:119443. doi: 10.1016/j.jad.2025.119443. Online ahead of print.PMID: 40398613

 

  1. Trend and Provider- and Organizational-Level Factors Associated With Early Palliative Care Billing Among Patients Diagnosed With Distant-Stage Cancers in 2010-2019 in the United States. Hu X, Kwon Y, Jiang C, Fan Q, Shi KS, Zheng ZJ, Zhao J, Warren JL, Yabroff KR, Han X.J Clin Oncol. 2025 May 20;43(15):1789-1799. doi: 10.1200/JCO-24-01935. Epub 2025 Mar 7.PMID: 40053887

 

  1. Real-world implementation of a noninvasive, AI-augmented, anemia-screening smartphone app and personalization for hemoglobin level self-monitoring. Mannino RG, Sullivan J, Frediani JK, George P, Whitson J, Tumlin J, Lyon LA, Tyburski EA, Lam WA.Proc Natl Acad Sci U S A. 2025 May 20;122(20):e2424677122. doi: 10.1073/pnas.2424677122. Epub 2025 May 13.PMID: 40359048

 

  1. Real World Data to Improve Outcomes in Retinal Vein Occlusion. Heath Jeffery RC, McAllister IL, Chen FK.Clin Exp Ophthalmol. 2025 May 20. doi: 10.1111/ceo.14547. Online ahead of print.PMID: 40390564 No abstract available.

 

  1. Prescribing Practices Among Psoriasis Experts for Patients with Concomitant Malignancy: A Survey of International Psoriasis Council Members. Bowe S, Murphy M, Bourke J, Ryan C.Clin Exp Dermatol. 2025 May 20:llaf198. doi: 10.1093/ced/llaf198. Online ahead of print.PMID: 40390599

 

  1. Real-world efficacy and safety of nivolumab and ipilimumab in metastatic renal cell carcinoma: a Polish multicenter study. Pacholczak-Madej R, Drobniak A, Stokłosa Ł, Grela-Wojewoda A, Calik J, Versuti Viegas N, Tusień-Małecka D, Szwiec M, Dobrzańska J, Roman A, Bidas A, Gawlik-Urban A, Walocha J, Blecharz P, Puskulluoglu M.Future Oncol. 2025 May 20:1-10. doi: 10.1080/14796694.2025.2508138. Online ahead of print.PMID: 40391586

 

  1. Center Volume Not Associated with Survival Benefit of Inter-Hospital Transfer for Pediatric Cardiac Surgery. Chauhan D, Mehaffey JH, Hayanga JWA, Verhoeven PA, Mathewson M, Godsey V, Fazi A, Udassi JP, Badhwar V, Mascio CE.Pediatr Cardiol. 2025 May 20. doi: 10.1007/s00246-025-03881-x. Online ahead of print.PMID: 40392277

 

  1. Management and Clinical Outcomes of Patients with Advanced Ovarian Cancer in Routine Clinical Practice in Spain: The OVOC Study. Quindós-Varela M, Soto de Prado-Otero D, Gallego A, García Y, Guerra E, Estévez-García P, Barretina-Ginesta MP, Borraz P, González-Martín A, Rubio MJ.Oncol Ther. 2025 May 20. doi: 10.1007/s40487-025-00347-1. Online ahead of print.PMID: 40392495 Free article.

 

  1. Real-world evidence from Japan regarding survival outcomes and treatment sequence in patients receiving CDK4/6 inhibitor plus endocrine therapy as first- or second-line treatment for hormone receptor-positive, HER2-negative advanced or metastatic breast cancer. Yoshinami T, Takano Y, Ozaki Y, Kajiwara Y, Yamamoto M, Watanabe KI, Tsukabe M, Fujisawa F, Nagai SE, Shibata N, Oshiro C, Bando H, Tsunoda N, Yamagami K, Koizumi K, Takada M, Toriguchi N, Sekine N, Kawaguchi T, Saji S, Sagara Y, Morita S, Masuda N.Breast Cancer. 2025 May 20. doi: 10.1007/s12282-025-01713-7. Online ahead of print.PMID: 40392524

 

  1. Association between herpes simplex virus type 1 and the risk of Alzheimer's disease: a retrospective case-control study. Liu Y, Johnston C, Jarousse N, Fletcher SP, Iqbal S.BMJ Open. 2025 May 20;15(5):e093946. doi: 10.1136/bmjopen-2024-093946.PMID: 40393802 Free article.

 

  1. EGFR exon 20 insertions mutation in lung adenocarcinoma and its response by high-dose of Furmonertinib: a real-world study. Yang S, Liu Y, Zhao J, He Z, Chen H, Ma S, Wu Y, Wu Y, Wang L, Zhang C, Wang Q.BMC Cancer. 2025 May 20;25(1):900. doi: 10.1186/s12885-025-14313-7.PMID: 40394562 Free PMC article.

 

  1. Venetoclax-based non-intensive combinations for relapsed/refractory acute myeloid leukaemia-Real-world data from a UK-wide programme. Wood H, O'Nions J, Chan WY, Borg A, Veitch S, Elder P, Jain M, Aries J, Leak S, Mitchell E, Pavlu J, Othman J, Dillon R, Mehta P, Murthy V, Knapper S, Potter V, Copland M, Craddock C, Krishnamurthy P.Br J Haematol. 2025 May 20. doi: 10.1111/bjh.20149. Online ahead of print.PMID: 40394961 No abstract available.

 

  1. Long-term safety and effectiveness of mepolizumab for patients with bronchial asthma in routine clinical practice in Japan - final report of special drug use investigation. Tsuboi E, Aoki H, Aizawa K, Komatsubara M, Howarth P.Respir Investig. 2025 May 20;63(4):651-659. doi: 10.1016/j.resinv.2025.05.003. Online ahead of print.PMID: 40398189

 

  1. Real-World Evidence Linking the Predicting Risk of Cardiovascular Disease Events Risk Score and Coronary Artery Calcium. Rhee AJ, Pandit K, Berger JS, Iturrate E, Coresh J, Khan SS, Shin JI, Hochman JS, Reynolds HR, Grams ME.J Am Heart Assoc. 2025 May 21:e038991. doi: 10.1161/JAHA.124.038991. Online ahead of print.PMID: 40396415 Free article. No abstract available.

 

  1. Epidemiology and healthcare utilization in motor neuron disease in Czechia. Kara NS, Zouharova A, Broulikova HM, Jarkovsky J, Slachtova L.Amyotroph Lateral Scler Frontotemporal Degener. 2025 May 21:1-9. doi: 10.1080/21678421.2025.2506441. Online ahead of print.PMID: 40396547 Free article.

 

  1. [Faricimab in previously treated neovascular age-related macular degeneration : Study design of the prospective noninterventional study PASSENGER]. Heimes-Bussmann B, Bellenbaum R, Njoo C, Liakopoulos S, Schmitz-Valckenberg S, Zortel M, Rothaus K, Leemhuis J, Mussinghoff P, Lommatzsch A. 2025 May 21. doi: 10.1007/s00347-025-02258-y. Online ahead of print.PMID: 40397174 German.

 

  1. Genitourinary syndrome of menopause: a multicenter study from the Indian Midlife Registry. Ashraf AB, Meeta M, Chitra AB, Pahwa S, Shah J, Mohi M, Reddy G, Aggarwal K, Sarkari A, Sharma S, Jaiswal J, Shah J, Sen B, Unni J, Mane S, Desai J. 2025 May 21:1-8. doi: 10.1080/13697137.2025.2496681. Online ahead of print.PMID: 40397455

 

  1. Treatment Patterns of Goserelin 3.6 mg Once Every 4 Weeks and 10.8 mg Once Every 12 Weeks in Women With Breast Cancer: A Real-World Analysis of Patients in the United States. McCann KE, Kaklamani V, Osman N, Cannon J, Brent L, Lucia R, Li C, Duran N, Gupta S, Martin N.JCO Oncol Pract. 2025 May 21:OP2400655. doi: 10.1200/OP-24-00655. Online ahead of print.PMID: 40397835

 

  1. Effect of chemotherapy timing in triple-negative breast cancer: a real-world evidence Graciano N, López L, Rodriguez CA, Montoya K, González DM, Gómez LR, Zapata ML, Cortés J.Breast Cancer Res Treat. 2025 May 21. doi: 10.1007/s10549-025-07716-4. Online ahead of print.PMID: 40399665

 

  1. Long-term outcomes following alternative second-line oral glucose-lowering treatments: Results from the real-world progression in type 2 diabetes mellitus United Kingdom (RAPIDS-UK) model. Carroll OU, Bidulka P, Basu A, Adler AI, O'Neill S, Briggs AH, Lugo-Palacios DG, Khunti K, Grieve R.Diabetes Obes Metab. 2025 May 21. doi: 10.1111/dom.16447. Online ahead of print.PMID: 40400097

 

  1. Multiple myeloma care, treatment patterns, and treatment durations in academic and community care settings. Boytsov N, McGuiness CB, Zhou Z, Huo T, Montgomery K, Kotowsky N, Chen CC.Future Oncol. 2025 May 21:1-14. doi: 10.1080/14796694.2025.2504318. Online ahead of print.PMID: 40400295 Free article.

 

  1. Real-world evidence for preoperative use of (chemo)radiotherapy with intensity modulation for locally advanced rectal cancer by the Colib French group. Pointreau Y, Blanchard N, Chamois J, Debelleix C, Gross E, Hémery CG, Passerat V, Schipman B.Cancer Radiother. 2025 May 21;29(3):104627. doi: 10.1016/j.canrad.2025.104627. Online ahead of print.PMID: 40403380

 

  1. Impact of availability of a highly effective Cystic Fibrosis treatment (elexacaftor/tezacaftor/ivacaftor) on lung transplant waitlist and lung transplantation trends in the US. Merlo C, Geiger JM, Wang Z, Lyden GR, Schladt DP, McGarry L.Respir Med. 2025 May 21:108171. doi: 10.1016/j.rmed.2025.108171. Online ahead of print.PMID: 40409741

 

  1. Management of Adverse Events During Treatment for Advanced Thyroid Cancer. Roberts TJ, Wirth LJ. 2025 May 22. doi: 10.1089/thy.2024.0755. Online ahead of print.PMID: 40401445 Review.

 

  1. Nasopharyngeal Carcinoma and Head and Neck Cancer in Type 2 Diabetes after SGLT2I, DPP4I, GLP1a Use. Li L, Chou OH, Mak KK, Yang Y, Chung CT, Li G, Chan CPL, Wong WT, Liu T, Cheung BMY, Tse G, Zhou J.Cancer Prev Res (Phila). 2025 May 22. doi: 10.1158/1940-6207.CAPR-24-0349. Online ahead of print.PMID: 40401748

 

  1. Treatment journey clustering with a novel kernel k-means machine learning algorithm: a retrospective analysis of insurance claims in bipolar I disorder. Littman M, Nguyen HB, Campbell J, Keyloun KR.Brain Inform. 2025 May 22;12(1):12. doi: 10.1186/s40708-025-00258-x.PMID: 40402327 Free PMC article.

 

  1. Real-World Utilization of Biologic and Targeted Synthetic Disease-Modifying Anti-rheumatic Drugs in Psoriatic Arthritis and Axial Spondyloarthritis: Insights from Sweden and Germany. Roque H, Dun AR, Cooper A, Kienzle S, Welby S, Wilke T, Song J, Abé C.Adv Ther. 2025 May 22. doi: 10.1007/s12325-025-03216-5. Online ahead of print.PMID: 40402376

 

  1. Comparative analysis of influenza healthcare disparities in the United States using retrospective administrative claims from Medicaid and commercial databases, 2015-2019. Matas JL, Raskina K, Tong S, Forney D, Scarpellini B, Cruz-Rivera M, Puckrein G, Xu L.PLoS One. 2025 May 22;20(5):e0321208. doi: 10.1371/journal.pone.0321208. eCollection 2025.PMID: 40402986 Free PMC article.

 

  1. Retreatment of Metastatic Castration-Resistant Prostate Cancer Patients with 223Ra Therapy in Daily Practice. van Riel JHHM, Donswijk ML, Brouwer C, Gerritsen WR, Tan-Phan TTH, Thimister PWL, Noordzij W, Te Beek ET, van Warmerdam LJC, Bergman AM, van Oort IM, Wyndaele DNJ, van der Doelen MJ.J Nucl Med. 2025 May 22:jnumed.125.269746. doi: 10.2967/jnumed.125.269746. Online ahead of print.PMID: 40404398

 

  1. Evaluation of post-market adverse events of lubiprostone: a real-world adverse event analysis from the FAERS database. Li Q, Zhang J, Yang C, Dong X, Wang Y.BMC Gastroenterol. 2025 May 22;25(1):395. doi: 10.1186/s12876-025-03987-9.PMID: 40405101 Free article.

 

  1. Patient characteristics and pharmacologic treatment patterns in antifibrotic-treated patients with fibrosing interstitial lung diseases: real-world results from a claims database. Kondoh Y, Ito T, Kimura H, Bao H, Kuwana M.BMC Pulm Med. 2025 May 22;25(1):253. doi: 10.1186/s12890-025-03713-x.PMID: 40405141 Free article.

 

  1. Comparative Analysis of Adverse Events Linked to PEG-rhG-CSF and rhG-CSF in Real-World Settings: Disproportionate Examination of the US Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) Database. Qu Y, Zuo L, Zhang S, Zhou W, Chen R.Clin Ther. 2025 May 22:S0149-2918(25)00159-6. doi: 10.1016/j.clinthera.2025.04.017. Online ahead of print.PMID: 40410065 Review.

 

  1. The Global Register of Alopecia areata disease Severity and treatment Safety - United Kingdom (GRASS-UK): importance of real-world data in alopecia areata. Harries M, Al-Nuaimi Y, Wall D, Chandidzura A, Ahmed S, Meah N.Clin Exp Dermatol. 2025 May 23;50(6):1250-1252. doi: 10.1093/ced/llaf055.PMID: 39891550 No abstract available.

 

  1. Diagnosis, management, and monitoring of interleukin-1 mediated diseases in Central and Eastern Europe: real-world data. Jelusic M, Sestan M, Toplak N, Tamas C, Vojinovic J, Zuber Z, Wolska-Kusnierz B, Sparchez M, Jesenak M, Rusoniene S, Stanevica V, Dolezalova P, Harel L, Uziel Y, Gattorno M.Pediatr Rheumatol Online J. 2025 May 23;23(1):56. doi: 10.1186/s12969-025-01105-3.PMID: 40405263 Free PMC article.

 

  1. Healthcare resource utilization and associated costs in patients with metastatic castration-resistant prostate cancer in Greece. Bournakis E, Bournakis A, Zolota DV, Kostouros E, Zagouri F, Papatheodoridi AP, Andrikopoulou A, Tsiatas M, Karalis K, Zakopoulou R, Mamali A, Christodoulou C, Binas I, Ardavanis A, Mauri D, Emmanouil G, Dimitriadis I, Bamias A.Expert Rev Pharmacoecon Outcomes Res. 2025 May 23. doi: 10.1080/14737167.2025.2505726. Online ahead of print.PMID: 40405599 Free article.

 

  1. Real-World Efficacy and Safety of Anti-PD-1 Antibody Therapy for Patients With Advanced Cutaneous Squamous Cell Carcinoma: A Single-Center Retrospective Study in Japan. Nakano E, Ogata D, Namikawa K, Yamazaki N.J Dermatol. 2025 May 23. doi: 10.1111/1346-8138.17799. Online ahead of print.PMID: 40407151

 

  1. Impact of the presence of a prosthetic implant and transition to oral stepdown therapy on relapse rates and mortality in uncomplicated Staphylococcus aureusbacteremia treated with 14 days of antibiotics: a retrospective cohort study. Blez D, Labarbe L, Grohs P, Mainardi J-L, Barnier J-P, Lebeaux D, Dubert M.Microbiol Spectr. 2025 May 23:e0333724. doi: 10.1128/spectrum.03337-24. Online ahead of print.PMID: 40407372 Free article.

 

  1. Protocol for Japan-acute retinal necrosis (J-ARN) registry: A combined prospective and retrospective cohort study. Usui Y, Kinouchi R, Nakano S, Iwahashi C, Hase K, Nagata K, Sugimoto M, Hasegawa E, Tsubota K, Kusuhara S, Akiyama M, Kashiwagi K, Takeda A, Kaburaki T, Goto H, Sonoda KH.PLoS One. 2025 May 23;20(5):e0323822. doi: 10.1371/journal.pone.0323822. eCollection 2025.PMID: 40408418 Free article.

 

  1. The analysis of strategic management decisions and corporate competitiveness based on artificial intelligence. Pu Y, Li H, Hou W, Pan X.Sci Rep. 2025 May 23;15(1):17942. doi: 10.1038/s41598-025-02842-x.PMID: 40410317 Free article.

 

  1. Evaluation of KRAS and NRAS mutations in metastatic colorectal cancer: an 8-year study of 10 754 patients in Turkey. Kavgaci G, Akiva I, Ozon YH, Berkil H, Karadayi H, Dizdar O, Yalcin S.Mol Oncol. 2025 May 23. doi: 10.1002/1878-0261.70042. Online ahead of print.PMID: 40411151 Free article.

 

  1. Establishment of adult reference interval of oxalate in spot urine using real-world data. Shen Y, Luo X, Guan Q, Lou W, Cheng L.Eur J Med Res. 2025 May 24;30(1):415. doi: 10.1186/s40001-025-02657-6.PMID: 40410837 Free article.

 

  1. Real-World 10-Year Outcomes of Anti-VEGF Therapy for Neovascular Age-Related Macular Degeneration: A Meta-Analysis. Spooner K, Broadhead G, Fraser-Bell S, Hong T, Wong JG, Chang AA.Clin Exp Ophthalmol. 2025 May 24. doi: 10.1111/ceo.14559. Online ahead of print.PMID: 40411432

 

  1. Using a Markov Model and Real-World Evidence to Identify the Most Cost-Effective Cholesterol Treatment Escalation Threshold for the Secondary Prevention of Cardiovascular Disease. Mariani A, Mohiuddin S, Muller P, Samarasekera E, Swain SA, Mills J, Patel R, Preiss D, Shantsila E, Downing BC, Lonergan M, Rowark S, Welton NJ, Williams R, Wonderling D.Appl Health Econ Health Policy. 2025 May 24. doi: 10.1007/s40258-025-00977-6. Online ahead of print.PMID: 40411656

 

  1. The patient journey and burden of disease in Demodexblepharitis in the United States. Periman LM, Whitley WO, Maiti S, Mun J, Ho AN, Oak B, Athavale A, Yeu E.J Med Econ. 2025 Dec;28(1):734-742. doi: 10.1080/13696998.2025.2500224. Epub 2025 May 21.PMID: 40314599 Free article.

 

  1. Patterns of co-administration and sequential administration of COVID-19 and influenza vaccinations: a US study using Adheris pharmacy dataset. Yehoshua A, Hu T, Pond T, Yang J, Welch V, Boikos C, Deng S, Zheng H, Sardana P, Agrawal N, Sharma M.Expert Rev Vaccines. 2025 Dec;24(1):433-443. doi: 10.1080/14760584.2025.2505766. Epub 2025 May 21.PMID: 40357570 Free article.

 

  1. Interleukin-23p19 inhibitors for the treatment of moderate-to-severe psoriasis: an expert opinion of real-world evidence studies in Europe. Ständer S, Thaçi D.J Dermatolog Treat. 2025 Dec;36(1):2438803. doi: 10.1080/09546634.2024.2438803. Epub 2025 May 21.PMID: 40396610 Free article.