2025 -  WEEK 19

What's New in RWE Research this Week

  1. The evolution and future of integrated evidence planning. Lee WC, Blanchette C, Pokras S, Shaikh J, Miller J.Expert Rev Pharmacoecon Outcomes Res. 2025 May 5:1-8. doi: 10.1080/14737167.2025.2497876. Online ahead of print.PMID: 40266581 Review.

 

  1. Clinical routine care for choriocarcinoma: a descriptive analysis of data from the Baden-Wuerttemberg Cancer Registry (BWCR). Taran FA, Wosnik A, Juhasz-Böss I, Burtscher K, Morakis P.Arch Gynecol Obstet. 2025 May 5. doi: 10.1007/s00404-025-08038-y. Online ahead of print.PMID: 40323395

 

  1. Predictors of response to burosumab in adults with X-linked hypophosphatemia: real-world data from an Italian cohort. Arcidiacono GP, Camozzi V, Tripepi G, Eller-Vainicher C, Vezzoli G, Brandi ML, Marcucci G, Girasole G, Aversa A, Vitale C, Cerbone G, D'Alessandro MM, Zaninotto M, Fusaro M, Torres MO, Cannito M, Cecchinato A, Diogo M, Peleg Falb M, Guidolin F, Zampogna M, Plebani M, Campello E, Simioni P, Sella S, Giannini S.J Endocrinol Invest. 2025 May 5. doi: 10.1007/s40618-025-02596-3. Online ahead of print.PMID: 40323576

 

  1. Evolution of treatment practices and outcomes in multiple myeloma during 2013-2022: a Finnish real world registry study. Partanen A, Waltari M, Vikkula J, Mattila R, Närhi K, Eeva J, Putkonen M.Acta Oncol. 2025 May 5;64:598-606. doi: 10.2340/1651-226X.2025.42647.PMID: 40325790 Free article.

 

  1. Real-world efficacy and tolerability of axitinib + pembrolizumab in the treatment of renal cell carcinoma. Ritter K, Strojny M, McCullough J, Law J.J Oncol Pharm Pract. 2025 May 5:10781552251331576. doi: 10.1177/10781552251331576. Online ahead of print.PMID: 40325928

 

  1. Analysis of adherence to ICS/LAMA/LABA in patients with asthma: a retrospective observational cohort study using medical claims data. Oga T, Ito R, Mita C, Takano M, Requena G, Mukai I, Yarita M.Respir Investig. 2025 May 5;63(4):569-575. doi: 10.1016/j.resinv.2025.04.017. Online ahead of print.PMID: 40328074

 

  1. Use of real-worlddata for the development and the follow-up of drugs in rare diseases. The example of immune thrombocytopenia and autoimmune hemolytic anemia. Moulis G, Zadro Y, Sommet A, Lapeyre-Mestre M, Lafaurie M.Rev Med Interne. 2025 May 5:S0248-8663(25)00505-3. doi: 10.1016/j.revmed.2025.03.424. Online ahead of print.PMID: 40328530 Review.

 

  1. Including non-randomised studies of interventions in meta-analyses of randomised controlled trials changed the estimates in more than a third of the studies: Evidence from an empirical analysis. Yao M, Mei F, Ma Y, Qin X, Huan J, Zou K, Li L, Sun X.J Clin Epidemiol. 2025 May 5:111815. doi: 10.1016/j.jclinepi.2025.111815. Online ahead of print.PMID: 40334718

 

  1. Vortioxetine for Cognitive Impairment in Major Depressive Disorder During Post-COVID Syndrome: Real-World Evidence. Guillen-Burgos HF, Galvez-Florez JF, Moreno-López S, Anaya JM, Kwan ATH, McIntyre RS.J Clin Psychiatry. 2025 May 5;86(2):24m15387. doi: 10.4088/JCP.24m15387.PMID: 40338259

 

  1. Perceptions of the effects of following specific diets among people with multiple sclerosis: A web scraping analysis of the multiple sclerosis subreddit. Kuhlman N, Lamm K, Wilson G, Klein B, Shuger Fox S, Titcomb TJ.Mult Scler Relat Disord. 2025 May 5;99:106504. doi: 10.1016/j.msard.2025.106504. Online ahead of print.PMID: 40345116

 

  1. The real-world effectiveness of ustekinumab in patients with ulcerative colitis in the United States. Burbage S, Knight H, Godwin B, Meadows R, Jones W, Zhao R, Kachroo S.Curr Med Res Opin. 2025 May 6:1-7. doi: 10.1080/03007995.2025.2494642. Online ahead of print.PMID: 40327500

 

  1. Real-worldData on Intermediate-risk Differentiated Thyroid Cancer Biochemical Response to 3700 or 5550 MBq of [131I]Sodium Iodide. Machado DM, Bulzico DA, Fontes LF, Mello RCR, Locatelli SB, Pujatti PB.Curr Radiopharm. 2025 May 6. doi: 10.2174/0118744710374569250415095218. Online ahead of print.PMID: 40329734

 

  1. Stress sensitivity, negative affect, and functioning in an early psychosis clinic. Bornheimer LA, Lapidos A, Simmonite M, Suzuki T, Tso IF, Taylor SF.Schizophr Res. 2025 May 6;281:125-131. doi: 10.1016/j.schres.2025.05.001. Online ahead of print.PMID: 40334438

 

  1. Incidence and Risk of Heart Failure in Patients with Coronary Heart Disease and Stroke: A Population-based Cohort Study. Liu X, Shen P, Chen Y, Sun Y, Chen Q, Lin H, Tang X, Gao P.Am J Cardiol. 2025 May 6:S0002-9149(25)00286-3. doi: 10.1016/j.amjcard.2025.04.028. Online ahead of print.PMID: 40339776

 

  1. Leveraging real-world data from administrative claims and medical records to inform safety and effectiveness of piperacillin-tazobactam in the management of pediatric hospital-acquired pneumonia. Blumenstock JA, Faerber JA, Menon M, Lawler R, Downes KJ, Kratz E, Erickson K, Haltzman-Cassenti B, Yildirim I, Hussaini L, Elmontser M, Sederdahl BK, Hahn A, Thomson J, Newland J, Terrill C, Bradley J, Zachariah P, Younus M, Mo J, Wible M, Tawadrous M, Fisher BT.Am J Epidemiol. 2025 May 7;194(5):1426-1435. doi: 10.1093/aje/kwae251.PMID: 39108170

 

  1. Emulating randomized trials by observational database studies: the RCT-DUPLICATE initiative in COPD and asthma. Suissa S, Schneeweiss S, Feldman WB, Tesfaye H, Wang SV.Am J Epidemiol. 2025 May 7;194(5):1152-1159. doi: 10.1093/aje/kwae319.PMID: 39191649

 

  1. The challenges of measuring socioeconomic inequality in pharmacoepidemiology studies. Prener C, Schley K, Miles A, Willis S.Am J Epidemiol. 2025 May 7;194(5):1160-1165. doi: 10.1093/aje/kwae360.PMID: 39289170

 

  1. Long-term delirium and survival outcomes in patients treated with GLP-1 receptor agonists versus metformin in type 2 diabetes: A population-based cohort study. Sun M, Wang X, Lu Z, Yang Y, Lv S, Miao M, Chen WM, Wu SY, Zhang J.Diabetes Obes Metab. 2025 May 7. doi: 10.1111/dom.16434. Online ahead of print.PMID: 40331425

 

  1. Validation of data quality in the Swedish quality register of gynecologic cancer for cervical cancer and vulvar cancer-a Swedish gynecologic cancer group (Swe-GCG) study. Bjurberg M, Hellman K, Säll TA, Staf C, Borgfeldt C, Holmberg E, Jönsson J, Lindahl G, Flöter Rådestad A, Sköld C, Bohlin KS, Stålberg K, Åvall-Lundqvist E, Kjølhede P, Dahm-Kähler P.Acta Obstet Gynecol Scand. 2025 May 7. doi: 10.1111/aogs.15152. Online ahead of print.PMID: 40331784

 

  1. Lublin Comorbidity of Adiposity Study (LUCAS 1.0 BMI) - quantifying the success of a region-wide overweight and obesity treatment program: a retrospective real-world data Lenart-Lipińska M, Gołacki J, Wronecki J, Matyjaszek-Matuszek B.Endokrynol Pol. 2025 May 7. doi: 10.5603/ep.102917. Online ahead of print.PMID: 40331834 Free article.

 

  1. The association between statins and gait speed reserve in older adults: effects of concomitant medication. De Spiegeleer A, Bronselaer A, Mahieu I, Vreys D, Haslbauer A, Leibfarth JP, Van Schoote L, Wakjira A, Petrovic M, Wynendaele E, De Spiegeleer B, Van Den Noortgate N, Kressig RW, Rössler R. 2025 May 7. doi: 10.1007/s11357-025-01682-x. Online ahead of print.PMID: 40332452

 

  1. Safety and Efficacy of Mirogabalin in Lumbar Spinal Stenosis Patients with Peripheral Neuropathic Pain on NSAIDs: Post Hoc Analysis of the MiroTAS Study. Nikaido T, Tabata S, Shiosakai K, Nakatani T, Sakoda H.Pain Ther. 2025 May 7. doi: 10.1007/s40122-025-00732-8. Online ahead of print.PMID: 40332730

 

  1. Variable selection in mixture cure models using elastic net penalty: application to COVID-19 data. Ramalata A, Adekpedjou A, Lesaoana M.PLoS One. 2025 May 7;20(5):e0320521. doi: 10.1371/journal.pone.0320521. eCollection 2025.PMID: 40334231 Free PMC article.

 

  1. Real-world analysis of treatment patterns, effectiveness, and safety of daratumumab-based regimens in Chinese patients with newly diagnosed or relapsed/refractory multiple myeloma. Wang L, Yang W, Wang Y, Niu T, Fu R, Zhong Y, Qian W, Ding K, Sun K, Liu H, Fang B, Liu H, Li Y, Yang Y, Zhuo J, Chen X, Cui C, Lu J.BMC Cancer. 2025 May 7;25(1):836. doi: 10.1186/s12885-025-13925-3.PMID: 40335949 Free PMC article.

 

  1. Macrovascular and microvascular complications in US Medicare enrollees with type 2 diabetes with and without atherosclerotic cardiovascular disease. Dunn TJ, Tan X, Harton J, Kim S, Xie L, Gamble C, Rotroff D.Diabetes Obes Metab. 2025 May 7. doi: 10.1111/dom.16441. Online ahead of print.PMID: 40341754

 

  1. Real-world evidence on effectiveness and safety of granulocyte transfusion (GT) during pre-engraftment phase in hematopoietic stem cell transplant patients: A single-centre study from north India, with mini-review of Indian studies on GT. Silwal P, Tiwari AK, Aggarwal G, Gupta S, Yadav SP, Sood N.Transfus Apher Sci. 2025 May 7;64(3):104127. doi: 10.1016/j.transci.2025.104127. Online ahead of print.PMID: 40345068

 

  1. Electronic health records-based research in Cardiology: the time has come for pragmatic trials. Seabra D, Oliveira A, Gavina C.Rev Port Cardiol. 2025 May 7:S0870-2551(25)00154-4. doi: 10.1016/j.repc.2024.12.007. Online ahead of print.PMID: 40345618 Review. English, Portuguese.

 

  1. Real-world effectiveness of ustekinumab versus anti-TNF or vedolizumab in ulcerative colitis: induction and 12-month maintenance results from the prospective, observational RUN-UC study. Bokemeyer B, Plachta-Danielzik S, Gilman E, Howaldt S, Mohl W, Efken P, Ehehalt R, Kahl M, Krause T, Trentmann L, Lügering A, Schnoy E, Jochum C, Hartmann P, Schreiber S.J Crohns Colitis. 2025 May 8;19(5):jjaf052. doi: 10.1093/ecco-jcc/jjaf052.PMID: 40152278

 

  1. The device-aided intrajejunal delivery of levodopa-entacapone-carbidopa intestinal gel the treatment of Parkinson's disease: overview of efficacy and safety. Popławska-Domaszewicz K, Metta V, Odin P, Chaudhuri KR.Expert Rev Med Devices. 2025 May 8:1-12. doi: 10.1080/17434440.2025.2499153. Online ahead of print.PMID: 40331578 Review.

 

  1. Clozapine acceptance and refusal rates for inpatients vs. outpatients with schizophrenia- secondary analyses of real-world data from a Danish quality assurance and improvement audit. Jakobsen MI, Nielsen J.Nord J Psychiatry. 2025 May 8:1-3. doi: 10.1080/08039488.2025.2499587. Online ahead of print.PMID: 40336324 No abstract available.

 

  1. Real-world characteristics and survival outcomes of patients with metastatic ALK fusion-positive solid tumors treated with standard-of-care therapies. Gadgeel SM, Fajardo O, Barlesi F, Eun Kim J, Kurzrock R, Thomas DM, Jagtiani R, Noe J, Schwemmers S, Nikolaidis C. 2025 May 8;30(5):oyaf005. doi: 10.1093/oncolo/oyaf005.PMID: 40338218 Free PMC article.

 

  1. Prospective Cohort Study of Trastuzumab Biosimilar CT-P6 in HER2-Positive Gastric Cancer: Japanese Real-World Outcomes. Taniguchi H, Nishikawa K, Haneji T, Izawa N, Imamura H, Yamaguchi H. Oncol Ther. 2025 May 8. doi: 10.1007/s40487-025-00341-7. Online ahead of print.PMID: 40338476 Free article.

 

  1. Continuous Glucose Monitoring in the Management of Medication in Care Home Residents with Type 2 Diabetes (eDMED): A Protocol for a Feasibility Study. Welford AE, Ridgeway J, Gillies C, Choudhary P, Hegde V, Khunti K, Seidu S. Diabetes Ther. 2025 May 8. doi: 10.1007/s13300-025-01740-9. Online ahead of print.PMID: 40338496

 

  1. The Effects of Dexamethasone in Cardiac Surgery: A Registry-Based, Real-World Data Analysis of Clinical Outcomes From the Netherlands Heart Registration. van Steenbergen GJ, Reniers T, De Bie Dekker A, Lensen IS, Noordzij PG, Rettig TCD, van Brakel T, Bouwman A, Olsthoorn JR; Cardiothoracic Surgery Registration Committee of the Netherlands Heart Registration.Anesth Analg. 2025 May 8. doi: 10.1213/ANE.0000000000007541. Online ahead of print.PMID: 40338876

 

  1. Comprehensive analysis of adverse event profile changes with pertuzumab addition to trastuzumab-based breast cancer therapy: Disproportionality analysis using VigiBase. Takeda T, Matsumoto J, Sakai T, Iwata N, Hamano H, Koyama T, Ariyoshi N, Zamami Y.Br J Clin Pharmacol. 2025 May 8. doi: 10.1002/bcp.70094. Online ahead of print.PMID: 40344285

 

  1. Pembrolizumab plus Lenvatinib in patients with metastatic Renal Cell Carcinoma: real-world evidences from the international ARON- 1 study. Porta C, Massari F, Taha T, Grande E, Bourlon MT, Kanesvaran R, Basso U, Molina-Cerrillo J, Alonso-Gordoa T, Myint ZW, Fornarini G, Buttner T, Park SH, Ürün Y, De Giorgi U, Pichler R, Rescigno P, Buchler T, Studentova H, Melichar B, Ansari J, Mollica V, Kucharz J, Rizzo M, Rizzo A, Kopp RM, Buti S, Monteiro FSM, Soares A, Bamias A, Santoni M.Cancer Immunol Immunother. 2025 May 9;74(7):196. doi: 10.1007/s00262-025-04019-x.PMID: 40343572

 

  1. Management and Burden of Hidradenitis Suppurativa: An Italian Hybrid Real-World Study. Balato A, Venturini M, Scalvenzi M, Foti C, Maifredi G, Creazzola SS, Antonacci S, Tonelli A, Valsecchi D, Vassellatti D, Cipelli R, Ori A, Casoli L.Dermatol Ther (Heidelb). 2025 May 9. doi: 10.1007/s13555-025-01407-0. Online ahead of print.PMID: 40343666

 

  1. Antibiotic use attributable to RSV infections during infancy-an international prospective birth cohort study. Hak SF, Venekamp RP, Billard MN, Cianci D, Van Houten MA, Pollard AJ, Heikkinen T, Cunningham S, Millar M, Martinon-Torres F, Dacosta-Urbieta A, Bont LJ, Wildenbeest JG; PROMISE Investigators.J Antimicrob Chemother. 2025 May 9:dkaf123. doi: 10.1093/jac/dkaf123. Online ahead of print.PMID: 40343736

 

  1. Clinical trials for Wolfram syndrome neurodegeneration: Novel design, endpoints, and analysis models. Wang G, Li ZA, Chen L, Lugar H, Hershey T.PLoS One. 2025 May 9;20(5):e0321598. doi: 10.1371/journal.pone.0321598. eCollection 2025.PMID: 40344084

 

  1. Machine Learning Prediction and Validation of Plasma Concentration-Time Profiles. Iwata H, Kageyama M, Handa K.Mol Pharm. 2025 May 9. doi: 10.1021/acs.molpharmaceut.4c01431. Online ahead of print.PMID: 40345671

 

  1. Improving the usability of grading scales for drug-induced ototoxicity with a focus on real world data Koot M, Crul M, van Balen D, Schutte T.Eur Arch Otorhinolaryngol. 2025 May 9. doi: 10.1007/s00405-025-09412-x. Online ahead of print.PMID: 40346416

 

  1. Identifying suppressive factors of Alzheimer's disease through comprehensive analysis of real-world data: a single-center retrospective study. Shiotani M, Hyohdoh Y, Hatakeyama Y, Kazui H, Okuhara Y.BMC Geriatr. 2025 May 9;25(1):321. doi: 10.1186/s12877-025-05982-x.PMID: 40346511

 

  1. Safety and effectiveness of vagus nerve stimulation in patients with drug-resistant epilepsy: a single center experience. Alwazna E, Abdullah J, Alsini H, Alshahrani M, Aldhafeeri W, Al-Attas A, Alshaikh A, Alanazi M, Alsahli H, Alshahrani M, Alshafi S, Tabarki B, Nazer A, Khan S.Acta Epileptol. 2025 May 9;7(1):28. doi: 10.1186/s42494-025-00215-5.PMID: 40346648

 

  1. Economic evaluation of Erdafitinib as a second-line treatment for advanced metastatic urothelial carcinoma: real-world data from the USA and prospective analysis from China. Li A, Wu M, Xie O, Xiang H, Meng K, Wan X.Future Oncol. 2025 May 10:1-9. doi: 10.1080/14796694.2025.2504321. Online ahead of print.PMID: 40346959

 

  1. Long-term effects of adding an SGLT-2 inhibitor to insulin therapy in patients with type 1 diabetes. An observational study and systematic review of real-world evidence. Maran A, Boscari F, Fagarazzi C, Crepaldi MC, Vedovato M, Bonora BM, Bruttomesso D, Morieri ML, Fadini GP.J Endocrinol Invest. 2025 May 10. doi: 10.1007/s40618-025-02602-8. Online ahead of print.PMID: 40347422

 

  1. Outcomes With Venetoclax 50 mg, Hypomethylating Agents, and Voriconazole or Posaconazole in Acute Myeloid Leukemia. Diebold K, Parker D, Worth S, Espinoza-Gutarra M, Vachhani P, Bachiashvili K, Rangaraju S, Mohty R, Bhatia R, Jamy O. 2025 May 6;6(3):e70049. doi: 10.1002/jha2.70049. eCollection 2025 Jun.PMID: 40330630 Free PMC article.