2025 -  WEEK 17

What's New in RWE Research this Week

  1. Population Pharmacokinetic Model for the Use of Intravenous or Subcutaneous Infliximab in Patients with Inflammatory Bowel Disease: Real-World Data from a Prospective Cohort Study. Song JH, Hong SN, Kim MG, Kim M, Kim SK, Kim ER, Chang DK, Kim YH.Gut Liver. 2025 Apr 21. doi: 10.5009/gnl240503. Online ahead of print.PMID: 40254990 Free article.

 

  1. Real-World Experience with FcRn Inhibitors Efgartigimod and Rozanolixizumab in Myasthenia Gravis: Administration in Multiple Cycles and Transition from Intravenous to Subcutaneous Formulation. Yoshikawa M, Inoue Y, Tanaka K, Tsumura K, Hoshino Y, Shichijo C, Ide T, Suzuyama K, Iwasaki M, Eriguchi M, Yukitake M, Takashima H, Koike H.Neurol Ther. 2025 Apr 21. doi: 10.1007/s40120-025-00748-4. Online ahead of print.PMID: 40257679

 

  1. Bridging ideal studies and real-world practice: the potential role of real-world evidence in reproductive medicine. Griesinger G. Reprod Biomed Online. 2025 Apr;50(4):104807. doi: 10.1016/j.rbmo.2025.104807. PMID: 40287211 Review.

 

  1. Cost-utility analysis of botulinum toxin type A versus oral drug treatment in patients with severe blepharospasm in Thailand. Hirunwiwatkul P, Permsuwan U, Ngamkiatphaisan S, Chirapapaisan N, Sriratanaban J.PLoS One. 2025 Apr 21;20(4):e0319926. doi: 10.1371/journal.pone.0319926. eCollection 2025.PMID: 40257973 Free PMC article.

 

  1. Revisiting the safety profile of tenofovir alafenamide: methodological reflections on real-world data. El-Kassas M, AlNaamani KM.Hepatol Int. 2025 Apr 21. doi: 10.1007/s12072-025-10829-z. Online ahead of print.PMID: 40259190 No abstract available.

 

  1. Identifying the diagnostic gap of tardive dyskinesia: an analysis of semi-structured electronic health record data. Griffiths K, Won Y, Lee Z, Wang L, Correll CU, Patel R.BMC Psychiatry. 2025 Apr 21;25(1):407. doi: 10.1186/s12888-025-06780-w.PMID: 40259324 Free PMC article.

 

  1. Real-World Insights into the Effectiveness and Tolerability of Onabotulinumtoxin A in Chronic Migraine: A Long-Term Evaluation of up to 11 Years. Santoro A, Fontana A, Copetti M, Miscio AM, d'Orsi G.Toxins (Basel). 2025 Apr 21;17(4):208. doi: 10.3390/toxins17040208.PMID: 40278706 Free PMC article.

 

  1. Inhaled corticosteroids for COVID-19: a real-world data analysis on guideline adherence. van Egeraat JW, Kuijpers T, Burgers J, van Os H, Chavannes NH, Bonten TN.BJGP Open. 2025 Apr 22:BJGPO.2024.0135. doi: 10.3399/BJGPO.2024.0135. Online ahead of print.PMID: 39592217 Free article.

 

  1. The role and value of real-worldevidence in health technology decision-making in France, Germany, Italy, Spain, and the UK: insights on external control arms. Vidalis A, Dumoulin O, Godbole M, Proenca CC.Int J Technol Assess Health Care. 2025 Apr 22;41(1):e25. doi: 10.1017/S0266462324004720.PMID: 40260460 Free PMC article.

 

  1. Exploring the Economic Impact of Cardiac Damage in Aortic Valve Replacement Patients: A Real-World Data Penta B, Tang GHL.Circ Cardiovasc Interv. 2025 Apr 22:e015358. doi: 10.1161/CIRCINTERVENTIONS.125.015358. Online ahead of print.PMID: 40260537 No abstract available.

 

  1. Identifying signals of disproportionate reporting for calcitonin gene-related peptide inhibitors: real-world evidence from the FDA adverse event reporting system. Lee N, Ok J, Kwon Y, Rhee SJ, Kim Y.Expert Opin Drug Saf. 2025 Apr 22. doi: 10.1080/14740338.2025.2497394. Online ahead of print.PMID: 40261259

 

  1. A comparison of healthcare resource utilization and costs between patients with chronic lymphocytic leukemia treated with first-line ibrutinib or acalabrutinib using two large US real-world databases. Rogers KA, Muluneh B, Qureshi ZP, He J, Bokun A, Ding Z, Lafeuille MH, Gogna P, Emond B, Fradley M.J Comp Eff Res. 2025 Apr 22:e240210. doi: 10.57264/cer-2024-0210. Online ahead of print.PMID: 40261261 Free article.

 

  1. Real-world data analysis of survival outcomes of patients with primary mediastinal large B-cell lymphoma treated with immunochemotherapy: the role of consolidative radiation therapy. Lee YP, Cho J, Ko YH, Oh D, Kim SJ, Kim WS, Yoon SE.Blood Res. 2025 Apr 22;60(1):27. doi: 10.1007/s44313-025-00076-4.PMID: 40261518 Free PMC article.

 

  1. Real-worldevidence in gynecologic cancers presented at key oncology conferences in the United States: Distribution and factors related to high-tier acceptance. Szamreta EA, Modi M, Periyasamy R, Yamsani B, Machiraju P, Menghani N, Monberg M.PLoS One. 2025 Apr 22;20(4):e0321654. doi: 10.1371/journal.pone.0321654. eCollection 2025.PMID: 40261873 Free PMC article.

 

  1. Assessing therapeutic decisions in generalized myasthenia gravis: Study protocol. Gutiérrez-Gutiérrez G, Gómez-Ballesteros R, Sotoca J, Ares A, Villaverde R, Reyes V, Armangué T, Salas E, Díaz-Abós P, Rebollo P, Sarmiento M, Escobar I, Maurino J, Querol L.PLoS One. 2025 Apr 22;20(4):e0322168. doi: 10.1371/journal.pone.0322168. eCollection 2025.PMID: 40261907 Free PMC article.

 

  1. Patterns of infectious complications and their implication on health system costs after esophagectomy for esophageal cancer: Real-world data from three European centers. Ledda AL, Tarantino I, Schiefer S, Ronellenfitsch U, Rebelo A, Sekulla C, Nienhüser H, Michalski C, Schmied B, Kleeff J, Klose J.Langenbecks Arch Surg. 2025 Apr 22;410(1):138. doi: 10.1007/s00423-025-03709-5.PMID: 40263193 Free PMC article.

 

  1. Post-marketing safety profile of ganirelix in women: a 20-year pharmacovigilance analysis of global adverse drug event databases (2004-2024). Yang Y, Cui Z, Feng X, Zou F, Wu X.BMC Pharmacol Toxicol. 2025 Apr 22;26(1):91. doi: 10.1186/s40360-025-00920-4.PMID: 40264185 Free PMC article.

 

  1. ICD-10-CM coding uncovers the gap between serological and clinically identified coeliac disease prevalence: A population-based study. Villar-Balboa I, Regí-Bosque M, Almeda-Ortega J, Cunillera-Puértolas O, Rando-Matos Y, Valencia-Pedraza I, Merino-Audí M, Arapovic-Amat I, Sánchez-Gómez N, Fernández-Gómez A, Salvador-González B, Sudrià-Lopez E, Martín-Cardona A, Fernández-Bañares F, Esteve M.Eur J Intern Med. 2025 Apr 22:S0953-6205(25)00141-4. doi: 10.1016/j.ejim.2025.04.010. Online ahead of print.PMID: 40268583

 

  1. Causal inference for time series datasets with partially overlapping variables. Gomez LA, Claassen J, Kleinberg S.J Biomed Inform. 2025 Apr 22;166:104828. doi: 10.1016/j.jbi.2025.104828. Online ahead of print.PMID: 40274036

 

  1. Caudal Epidural Steroid Injections: A Retrospective Pilot Study of Safety and Patient-Reported Outcomes. Hasoon J, Viswanath O, Orhurhu V, Abd-Elsayed A.Orthop Rev (Pavia). 2025 Apr 22;17:134102. doi: 10.52965/001c.134102. eCollection 2025.PMID: 40276362 Free PMC article.

 

  1. Impact of hospital surgical volume on in-hospital outcomes of peripartum hysterectomy: A nationwide retrospective cohort study. Sugai S, Sasabuchi Y, Yasunaga H, Kimura Y, Matsui H, Fushimi K, Yoshihara K, Nishijima K.Int J Gynaecol Obstet. 2025 Apr 23. doi: 10.1002/ijgo.70169. Online ahead of print.PMID: 40265238

 

  1. The evolution and future of integrated evidence planning. Lee WC, Blanchette C, Pokras S, Shaikh J, Miller J.Expert Rev Pharmacoecon Outcomes Res. 2025 Apr 23. doi: 10.1080/14737167.2025.2497876. Online ahead of print.PMID: 40266581 Review.

 

  1. The safety analysis of Lurasidone based on the real-world data of FAERS database. Luo Z, Zhang M, Liang W, Hu M, Jiang Y, Lei X, Wang Z, Zhu J, Du Y, Liu Y, Yang C.Expert Opin Drug Saf. 2025 Apr 23. doi: 10.1080/14740338.2025.2498054. Online ahead of print.PMID: 40266634

 

  1. Estimating the potential health economic value of introducing universal opt-out testing for HIV in emergency departments in Italy. d'Arminio Monforte A, d'Ettorre G, Galardo G, Lani E, Kagenaar E, Huntington S, Jarrett J, Ruf M, Ricciardi W.Eur J Public Health. 2025 Apr 23:ckaf057. doi: 10.1093/eurpub/ckaf057. Online ahead of print.PMID: 40267401

 

  1. Real-world comparative effectiveness and safety of Pertuzumab in patients with HER2+ metastatic breast cancer: A pan-Canadian population-based cohort study. Muñoz CE, Dai WF, Cheung WY, de Oliveira C, Pataky RE, Ding PQ, Tran DA, Aurangzeb Z, Nagamuthu C, Liu N, Lethbridge L, McClure C, Vriends K, Xiong H, Folkins C, Somayaji C, Peacock S, Alvi R, Turner D, O'Conaill C, McDonald T, Urquhart R, Kendell C, Dowden J, Strumpf E, Denburg A, Beca JM, Mercer RE, Tadrous M, Takhar P, Chan KKW; CanREValue Collaboration.Int J Cancer. 2025 Apr 23. doi: 10.1002/ijc.35448. Online ahead of print.PMID: 40268528

 

  1. Optimal timing of cancer treatments: a call for emerging evidence from clinical trials and real-world studies. Zhang J, Venchiarutti R, Wang X, He Q.Br J Cancer. 2025 Apr 23. doi: 10.1038/s41416-025-03030-4. Online ahead of print.PMID: 40269312 Review.

 

  1. Primary and postoperative radiotherapy in acute neurological symptoms due to malignant spinal compression: retrospective analysis from a German university hospital. Guhlich M, Maag TE, Schirmer MA, Chacón Quesada TA, Mielke D, Rieken S, Leu M, Dröge LH.BMC Cancer. 2025 Apr 23;25(1):759. doi: 10.1186/s12885-025-14106-y.PMID: 40269784 Free PMC article.

 

  1. Stereotactic body radiation therapy and thermal ablation for treatment of patients with pulmonary metastases: a systematic literature review and meta-analysis. Laeseke P, Ng C, Ferko N, Naghi A, Wright GWJ, Wang D, Laidlaw A, Kalsekar I, Amos T, Laxmanan B, Ghosh SK, Zhou M, Szapary P, Pritchett M.BMC Pulm Med. 2025 Apr 23;25(1):188. doi: 10.1186/s12890-025-03561-9.PMID: 40269808 Free PMC article.

 

  1. Burden of disease of Alzheimer disease in Italy: a real-world data Mennini FS, Sciattella P, Scortichini M, Migliorini R, Trabucco Aurilio M, Marcellusi A, Bianchetti A.BMC Health Serv Res. 2025 Apr 23;25(1):588. doi: 10.1186/s12913-025-12735-4.PMID: 40269923 Free PMC article.

 

  1. A framework to create, evaluate and select synthetic datasets for survival prediction in oncology. Christoforou AT, Spohn SKB, Sprave T, Fechter T, Rühle A, Nicolay NH, Popp I, Grosu AL, Peeken JC, Thieme AH, Stylianopoulos T, Strouthos I, Ferentinos K, Roussakis Y, Zamboglou C.Comput Biol Med. 2025 Apr 23;192(Pt A):110198. doi: 10.1016/j.compbiomed.2025.110198. Online ahead of print.PMID: 40273819

 

  1. Evaluation of Perioperative Cardiovascular Event Risk in Gastrointestinal Surgery- Predictive Modeling and Risk Stratification Using Machine Learning. Ito H, Seki T, Kawazoe Y, Takiguchi T, Akagi Y, Kubota K, Miyake K, Okada M, Ohe K.Circ J. 2025 Apr 24. doi: 10.1253/circj.CJ-25-0032. Online ahead of print.PMID: 40268474 Free article.

 

  1. Efficacy and Safety of Excimer Laser Coronary Atherectomy in Acute Coronary Syndrome: Real-World Evidence From a Propensity-Adjusted Analysis. Iiya M, Arai R, Nakada K, Okazawa H, Yoshikawa H, Hanyu Y, Kobayashi I, Onishi Y.Catheter Cardiovasc Interv. 2025 Apr 24. doi: 10.1002/ccd.31557. Online ahead of print.PMID: 40269647

 

  1. From concept to approval: human genomic data integration with population observational data - insights from a Belgian pilot study. Van Goethem N, Van der Heyden J, Smith P, Van Hoof W, De Schutter H, Van Bossuyt M, De Ridder K, Van Den Bulcke M, Cauët E.Arch Public Health. 2025 Apr 24;83(1):112. doi: 10.1186/s13690-025-01581-9.PMID: 40270042 Free PMC article.

 

  1. Assuring End-to-End Data Quality for Analytics on FHIR. Ziegler J, Fischer C, Volkmer PC, Erpenbeck M, Mang JM, Ganslandt T, Prokosch HU, Gulden C.Stud Health Technol Inform. 2025 Apr 24;324:57-62. doi: 10.3233/SHTI250161.PMID: 40270385

 

  1. FOX BOXes as Fundamental Enablers for EHR-Standardised Data Sharing - Building the Austrian Health Data Donation Space. Donsa K, Mangesius P, Lauschensky A, Baumgartner M, Tanjga N, Beyer S, Schreier G, Kreiner K.Stud Health Technol Inform. 2025 Apr 24;324:198-204. doi: 10.3233/SHTI250187.PMID: 40270411

 

  1. Empowering Nursing Care Through Digital Innovation. Nantschev R, Zoebinger E, Libiseller A, Ban M, Wilfling D, Lichtenegger K.Stud Health Technol Inform. 2025 Apr 24;324:205-206. doi: 10.3233/SHTI250188.PMID: 40270412

 

  1. Towards Improved Trial Recruitment Through Patient/Citizen-Driven Data Donation of Electronic Health Records in Austria. Ovejero S, Bezzi C, Huber S, Harrer J, Lauschensky A, Donsa K.Stud Health Technol Inform. 2025 Apr 24;324:240-245. doi: 10.3233/SHTI250195.PMID: 40270419

 

  1. The evolving role of real-world in medical device approvals in the United States. Goswami S, Masurkar PP, Kaul A.Expert Rev Med Devices. 2025 Apr 24. doi: 10.1080/17434440.2025.2498458. Online ahead of print.PMID: 40272412 No abstract available.

 

  1. Untangling the Biosimilars Interchangeability Puzzle: A Provocative Dive into Concepts and Terminology, and Developing a Strategy to Minimize Uncertainties from Interchangeability. Ghorab DM, Abdelfattah KM, Ibrahim HK, Elmorsy SAA.Ther Innov Regul Sci. 2025 Apr 24. doi: 10.1007/s43441-025-00765-3. Online ahead of print.PMID: 40272706 Review.

 

  1. COVID-19 pandemic and risk factor measurement in individuals with cardio-renal-metabolic diseases: A retrospective study in the United Kingdom. Shabnam S, Zaccardi F, Yates T, Islam N, Razieh C, Chudasama YV, Banerjee A, Seidu S, Khunti K, Gillies CL.PLoS One. 2025 Apr 24;20(4):e0319438. doi: 10.1371/journal.pone.0319438. eCollection 2025.PMID: 40273067 Free PMC article.

 

  1. Evidence-Based Clinical Protocols to Monitor Efficacy of [(177)Lu]Lu-PSMA Radiopharmaceutical Therapy in Metastatic Castration-Resistant Prostate Cancer Using Real-World Data. Unterrainer LM, De Leiris N, Unterrainer M, Delker A, Hempel L, Ells Z, Kunte SC, Zahner J, Holzgreve A, Zacherl MJ, Sheikh GT, Casuscelli J, Leenhardt J, Pienta KJ, Jacquet E, Laramas M, Long J, Faure M, Reboulet G, Paller CJ, Mercier A, Solnes LB, Kiraz K, Ilhan H, Gafita A, Djaileb L.J Nucl Med. 2025 Apr 24:jnumed.124.269431. doi: 10.2967/jnumed.124.269431. Online ahead of print.PMID: 40274370

 

  1. Real-world effectiveness of adding newer generation GLP-1RA to SGLT2i in type 2 diabetes. Chaiyakunapruk N, Tan X, Liang Y, Guevarra M, Xie L, Cheng AYY.Cardiovasc Diabetol. 2025 Apr 24;24(1):177. doi: 10.1186/s12933-025-02737-1.PMID: 40275332 Free PMC article.

 

  1. Newborn screening facilitates early theranostics and improved spinal muscular atrophy outcome: five-year real-world evidence from Taiwan. Wang CH, Hsu TR, Liu MY, Wang LY, Chou IJ, Lee WT, Liang WC, Lee IC, Chen HJ, Kao SM, Ho HC, Niu DM, Hsiao KJ, Chang MY, Hsieh HM, Jong YJ.Orphanet J Rare Dis. 2025 Apr 24;20(1):197. doi: 10.1186/s13023-025-03697-1.PMID: 40275389 Free PMC article.

 

  1. Promising results but caution needed in GLP-1RA large scale epidemiology. Deo SV, Sattar NA.Trends Endocrinol Metab. 2025 Apr 24:S1043-2760(25)00075-X. doi: 10.1016/j.tem.2025.03.015. Online ahead of print.PMID: 40280862

 

  1. Influenza burden among chronic condition and immunocompromised patients in the United States. Bhounsule P, Boundy K, Mehle S, Chang M, Sedgley R, Vasey J.Curr Med Res Opin. 2025 Apr 25:1-9. doi: 10.1080/03007995.2025.2492646. Online ahead of print.PMID: 40265201

 

  1. Real-World Evidence in New Drug and Biologics License Application Approvals During Fiscal Years 2020-2022. Innes GK, Smith KA, Kuzucan A, Li J, Rivera D, Panagiotou OA, Concato J.Clin Pharmacol Ther. 2025 Apr 25. doi: 10.1002/cpt.3688. Online ahead of print.PMID: 40276902

 

  1. LDL-C Reduction with Evolocumab Among Patients with ASCVD in China: Real-World Evidence from Tianjin Metropolitan Area. Zhao L, Liu J, Liu Y, Huang Z, Ye X, Lange JL, Dhalwani N, Yang F, Zhang Z, Chen K, Zhang H, Zhou J.Adv Ther. 2025 Apr 25. doi: 10.1007/s12325-025-03199-3. Online ahead of print.PMID: 40279014

 

  1. The protective effects of insulin on the developing of dementia in chronic kidney disease patients with hypertension and diabetes: a population-based nationwide study. Chen YY, Chen YH, Fang YW, Wang JT, Tsai MH.BMC Nephrol. 2025 Apr 25;26(1):211. doi: 10.1186/s12882-025-04145-9.PMID: 40281491

 

  1. Efficacy and Safety of IL-17 and IL-23 Inhibitors in Elderly Patients With Plaque Psoriasis: A Real-World Study. Hacınecipoğlu F, Çelik G, Kartal SP.J Dermatol. 2025 Apr 26. doi: 10.1111/1346-8138.17755. Online ahead of print.PMID: 40285439

 

  1. Short-term outcomes of triplet therapy in metastatic hormone-sensitive prostate cancer in older adults: a retrospective, single-center real-world cohort study. Usui K, Kubo H, Matsumoto T, Aigase T, Suzuki A, Kishida T, Nakaigawa N.Int Urol Nephrol. 2025 Apr 26. doi: 10.1007/s11255-025-04465-7. Online ahead of print.PMID: 40285804

 

  1. Post-marketing safety of pralsetinib: a real-world disproportionality analysis based on the FDA adverse event reporting system database. Shi Z, Shao K, Wang K, Xu M, Yu X, Xu C, Li Q, Song Z.Int J Clin Pharm. 2025 Apr 26. doi: 10.1007/s11096-025-01917-z. Online ahead of print.PMID: 40285824

 

  1. Care-seeking and treatment pathways of multidrug-resistant tuberculosis patients: an analysis of real-world data from regional health information system in Ningbo City in Eastern China. Chen B, Li Y, Peng Y, Zhou L, Chen XY, Ren YL, Luo D, Ling YX, Zhou YQ, Jiang JM, Xu B.Ann Med. 2025 Dec;57(1):2496405. doi: 10.1080/07853890.2025.2496405. Epub 2025 Apr 21.PMID: 40259579 Free PMC article.