2025 -  WEEK 16

What's New in RWE Research this Week

  1. Real-World Effectiveness of Single-Inhaler Triple Treatment Through Assorted Respiratory Outcomes When Switched From Multiple-Inhaler Triple Therapies (RESTART): A Prospective Cohort Study of Korean Patients With COPD. Lim H, Kim DH, Hong SH, Shin J, Lee H, Shin K, Ra SW, Lee SJ. Int J Chron Obstruct Pulmon Dis. 2025 Apr 11;20:1039-1050. doi: 10.2147/COPD.S499686. eCollection 2025. PMID: 40236761 Free PMC article.

 

  1. Safety of iGlarLixi in Japanese People with Type 2 Diabetes: A Post-marketing Database Study. Kaneto H, Hatanaka M, Morimoto Y, Takahashi Y, Terauchi Y. Adv Ther. 2025 May;42(5):2168-2189. doi: 10.1007/s12325-025-03135-5. Epub 2025 Mar 8. PMID: 40056372 Free PMC article.

 

  1. Real-world analyses of major adverse cardiovascular events and mortality risk after androgen deprivation therapy initiation in black vs. white prostate cancer patients. Moul JW, Boldt-Houle DM, Roach M 3rd.Prostate Cancer Prostatic Dis. 2025 Apr 18. doi: 10.1038/s41391-025-00963-y. Online ahead of print.PMID: 40251347

 

  1. A Canadian Real-World Study of Fixed-DOSE combination of Halobetasol Propionate 0.01%/Tazarotene 0.045% Lotion for the Treatment of Moderate-to-Severe Plaque Psoriasis. Vender R, Lynde C, Prajapati V, Zeinab R, Legault M, Hong HH, Barakat M.Clin Ther. 2025 Apr 18:S0149-2918(25)00081-5. doi: 10.1016/j.clinthera.2025.03.005. Online ahead of print.PMID: 40253236

 

  1. Inadequate Response to PCSK9 Inhibitors. Bimal T, Ayyalu T, Safarova MS, Donahoe S, Davila C, Dayspring T, Shapiro M, Gianos E.JACC Case Rep. 2025 Apr 16;30(8):103696. doi: 10.1016/j.jaccas.2025.103696.PMID: 40250948

 

  1. Comparative effectiveness of dupilumab versus mepolizumab and benralizumab in asthma: a multinational retrospective cohort study. Hung CT, Hung YC, Suk CW.J Allergy Clin Immunol Pract. 2025 Apr 16:S2213-2198(25)00372-1. doi: 10.1016/j.jaip.2025.04.015. Online ahead of print.PMID: 40250559

 

  1. Pembrolizumab after platinum-based chemotherapy for metastatic urothelial cancer: comparison between patients from a Dutch nationwide cohort and KEYNOTE-045. Richters A, Suelmann B, Franken M, Mehra N, Rikhof B, Westgeest H, Aben K, Robbrecht D; ProBCI Study Group.Cancer Treat Res Commun. 2025 Apr 15;43:100931. doi: 10.1016/j.ctarc.2025.100931. Online ahead of print.PMID: 40250101

 

  1. Attention in surgical phase recognition for endoscopic pituitary surgery: Insights from real-world data. González-Cebrián Á, Bordonaba S, Pascau J, Paredes I, Lagares A, de Toledo P.Comput Biol Med. 2025 Apr 17;191:110222. doi: 10.1016/j.compbiomed.2025.110222. Online ahead of print.PMID: 40249993

 

  1. Upadacitinib Drug Survival in the Management of Patients With Moderate to Severe Atopic Dermatitis: Real-Time Data From the Biogrid Database Registry. Abu-Ghazaleh N, Ross G, Morgan V.Australas J Dermatol. 2025 Apr 18. doi: 10.1111/ajd.14469. Online ahead of print.PMID: 40248987

 

  1. A Transformer-Based Framework for Counterfactual Estimation of Antihypertensive Treatment Effect on COVID-19 Infection Risk - A Proof-of-Concept Study. Qb Tran T, Lip S, Wu H, Visweswaran S, Pell JP, Padmanabhan S.Am J Hypertens. 2025 Apr 18:hpaf055. doi: 10.1093/ajh/hpaf055. Online ahead of print.PMID: 40247607

 

  1. Characteristics of type 2 diabetes patients with overt cardiovascular diseases in Malaysia: the real-worldevidence from the National Diabetes Registry. Wan KS, Hairi NN, Mustapha F, Mohd Yusoff MF, Ismail M, Moy FM, Ahmad NA.BMC Res Notes. 2025 Apr 17;18(1):183. doi: 10.1186/s13104-025-07204-4.PMID: 40247426 Free article.

 

  1. Effectiveness of a delegated primary care model in rural areas: design and methodology of a longitudinal observational study. Bräuer J, Lörzing R, Nagel E, Emmert M, Hofmann R.BMC Health Serv Res. 2025 Apr 18;25(1):567. doi: 10.1186/s12913-025-12742-5.PMID: 40247290 Free article.

 

  1. Real-world application of targeted next-generation sequencing for identifying molecular variants in Asian non-small-cell lung cancer. Wang FY, Yeh YC, Lin SY, Wang SY, Chen PC, Chou TY, Ho HL.BMC Cancer. 2025 Apr 17;25(1):715. doi: 10.1186/s12885-025-14016-z.PMID: 40247220 Free article.

 

  1. Re-assessing the risk-benefit profile of Thiazolidinediones: Cardiovascular Risks and Stroke Prevention Through Real-World Data. Fei L, Zhao Y.Endocr Pract. 2025 Apr 15:S1530-891X(25)00118-1. doi: 10.1016/j.eprac.2025.04.004. Online ahead of print.PMID: 40246234

 

  1. Real-World Impact of Pharmacogenomic Testing on Medication Use and Healthcare Resource Utilization in Patients With Major Depressive Disorder. Del Tredici AL, Johnson HL, DeHart B, Gutin A, Morin P, Kasten CR, Becker L, Johansen Taber K, Chawla D, Nierenberg AA.J Clin Psychopharmacol. 2025 Apr 18. doi: 10.1097/JCP.0000000000001999. Online ahead of print.PMID: 40245843

 

  1. Real-world (RW) study of outcomes for acute myeloid leukemia (AML) patients treated with glasdegib or venetoclax in US community oncology practices. Savill KMZ, Kish JK, Lee CH, Pathak P, D'Amico P, Russell-Smith A, Gajra A.Expert Rev Hematol. 2025 Apr 17. doi: 10.1080/17474086.2025.2492886. Online ahead of print.PMID: 40245377

 

  1. The role of sodium zirconium cyclosilicate drug utilization in managing hyperkalemia: impact on healthcare resource utilization and on maintenance of renin-angiotensin-aldosterone system inhibitor therapy in Italian clinical practice. Gnesi M, Daniel F, Mongelli V, Merlo A, Cosentino N, Maurizi AR, Nugnes M, Leogrande M, Degli Esposti L.J Med Econ. 2025 Dec;28(1):576-585. doi: 10.1080/13696998.2025.2487357. Epub 2025 Apr 17.PMID: 40244700 Free article.

 

  1. Safety and effectiveness of brolucizumab in patients with neovascular age-related macular degeneration: A phase IV study from India. Ghosh AK, Chakraborty D, Sudhalkar A, Chawla R, Singh SR, Sahu AK, Venkatesh R, Raval V, Shah S, Preetha P, Bhavsar M, Patil S, Khadke I, Thorat A.Indian J Ophthalmol. 2025 Apr 17. doi: 10.4103/IJO.IJO_1914_24. Online ahead of print.PMID: 40243051 Free article.

 

  1. Comparison of clinical outcomes of phacoemulsification with implantation of two new aspheric intraocular lenses: Real-worlddata. Bassi ST.Indian J Ophthalmol. 2025 Apr 17. doi: 10.4103/IJO.IJO_2395_24. Online ahead of print.PMID: 40243049 Free article.

 

  1. Development of an Australasian Dermatology Registry. Armstrong J, Baker C, Foley P.Australas J Dermatol. 2025 Apr 17. doi: 10.1111/ajd.14468. Online ahead of print.PMID: 40243029

 

  1. Hepatobiliary disorders and Direct-Acting Antiviral (DAA) therapies: real-world evidence and insights from the EudraVigilance database. Scicluna J, Di Napoli R, Pirozzi D, Fraenza F, Cardillo M, Scavone C, Capuano A.Expert Opin Drug Saf. 2025 Apr 18:1-8. doi: 10.1080/14740338.2025.2495180. Online ahead of print.PMID: 40243008

 

  1. Generating real-world evidence in early Alzheimer's disease: Considerations for applying the target trial emulation framework to study the safety of anti-amyloid therapies. Li X, Singh S, Rasouli B, Lyons J, Cocoros NM, Platt R, Abi-Elias I, Gurwitz JH.Alzheimers Dement (N Y). 2025 Apr 15;11(2):e70080. doi: 10.1002/trc2.70080. eCollection 2025 Apr-Jun.PMID: 40242567 Free PMC article.

 

  1. Real-world adherence to multi-target stool DNA testing for colorectal cancer screening among average risk Hispanic adults in the United States from 2016 to 2023. Greene M, Camardo M, Ozbay AB, López JVR, Limburg P, Duarte M.Curr Med Res Opin. 2025 Apr 17:1-13. doi: 10.1080/03007995.2025.2492681. Online ahead of print.PMID: 40241661

 

  1. Combining machine learning and dynamic system techniques to early detection of respiratory outbreaks in routinely collected primary healthcare records. Borges DGF, Coutinho ER, Cerqueira-Silva T, Grave M, Vasconcelos AO, Landau L, Coutinho ALGA, Ramos PIP, Barral-Netto M, Pinho STR, Barreto ME, Andrade RFS.BMC Med Res Methodol. 2025 Apr 16;25(1):99. doi: 10.1186/s12874-025-02542-0.PMID: 40241011 Free PMC article.

 

  1. Efficacy analysis and prognostic factors of first-line chemotherapy combined with immunotherapy in extensive-stage small cell lung cancer: a real-world study. Zhou JX, Sun YC, Xiao L, Lu HL, Yin XM, Fan K, Zhou YN.Sci Rep. 2025 Apr 16;15(1):13063. doi: 10.1038/s41598-025-98018-8.PMID: 40240495 Free PMC article.

 

  1. Safety And Efficacy Of Mechanical Thrombectomy In Distal Medium Vessel Occlusions: Experience And Real-World Data From An Italian Stroke Hub Centre. Alessiani M, Bonura A, Iaccarino G, Rossi SS, Mangiardi M, Bravi MC, Pezzella FR, de Rubeis G, Pampana E, Anticoli S.J Stroke Cerebrovasc Dis. 2025 Apr 14:108321. doi: 10.1016/j.jstrokecerebrovasdis.2025.108321. Online ahead of print.PMID: 40239825

 

  1. How to Refine and Prioritize Key Performance Indicators for Digital Health Interventions: Tutorial on Using Consensus Methodology to Enable Meaningful Evaluation of Novel Digital Health Interventions. McCabe C, Connolly L, Quintana Y, Weir A, Moen A, Ingvar M, McCann M, Doyle C, Hughes M, Brenner M.J Med Internet Res. 2025 Apr 16;27:e68757. doi: 10.2196/68757.PMID: 40239207 Free article.

 

  1. Comparative Effectiveness of Bile Acid Sequestrants and Antibiotics in the Management of Acute Pouchitis: A Matched Cohort Study from the United States. Alsakarneh S, Camilleri M, Farraye FA, Hashash JG.Dig Dis Sci. 2025 Apr 16. doi: 10.1007/s10620-025-09039-2. Online ahead of print.PMID: 40237906

 

  1. Correction to: Abrocitinib as a novel therapeutic approach for refractory prurigo nodularis: real world evidence. Demirbas A, Diremsizoglu E, Cınar G, Vural C.Arch Dermatol Res. 2025 Apr 16;317(1):712. doi: 10.1007/s00403-025-04217-8.PMID: 40237864 No abstract available.

 

  1. Supplementing Single-Arm Trials with External Control Arms-Evaluation of German Real-World Data. Russek M, Peltner J, Haenisch B.Clin Pharmacol Ther. 2025 Apr 16. doi: 10.1002/cpt.3684. Online ahead of print.PMID: 40237254

 

  1. Analysis of "Performance of an Automated Insulin Delivery System in People Living With Type 2 Diabetes and Insulin Resistance: First Real-World Evidence in 26,427 Users". Ahn DT.J Diabetes Sci Technol. 2025 Apr 16:19322968251328650. doi: 10.1177/19322968251328650. Online ahead of print.PMID: 40237140 Free PMC article.

 

  1. PD-L1 Testing, Treatment Patterns, and Clinical Outcomes Among Patients with Metastatic NSCLC at an Academic Medical Center, 2017-2021. Altan M, Sui D, Xu C, Simon GR, Sulihem ST, Malveaux D, Ponce D, Rinsurongkawong W, Rinsurongkawong V, Lee JJ, Zhang J, Gibbons DL, Vaporciyan AA, Heymach JV, Santorelli ML, Burke T, Williams LA.J Immunother Precis Oncol. 2025 Apr 14;8(2):161-171. doi: 10.36401/JIPO-24-26. eCollection 2025 May.PMID: 40235643 Free PMC article.

 

  1. Realworld evidence of insulin and biosimilar insulin therapy-Opportunities to improve adherence, outcomes and cost-effectiveness. Yang A, Yu J, Cheung JTK, Chan JCN, Chow E.Diabetes Obes Metab. 2025 Apr 15. doi: 10.1111/dom.16386. Online ahead of print.PMID: 40235124

 

  1. Long-term trends in the clinical management and outcomes of patients with gastroesophageal cancer in Norway. Kolstad A, Emanuel G, Hjortland GO, Nilssen Y, Ulvestad M, Areffard A, Aahlin EK.Acta Oncol. 2025 Apr 15;64:540-549. doi: 10.2340/1651-226X.2025.43167.PMID: 40235057 Free article.

 

  1. Treatment pathways and clinical outcomes in newly diagnosed multiple myeloma outside Europe and North America: The INTEGRATE study. Kim K, Verburgh E, Mitina T, Chen W, Yeh SP, Schutz N, Alsharif F, Chng WJ, Huang Z, Beksac M.Int J Hematol. 2025 Apr 15. doi: 10.1007/s12185-025-03972-8. Online ahead of print.PMID: 40234349

 

  1. Complete/Near-Complete Itch Response Observed in Patients with Moderate-to-Severe Atopic Dermatitis Initiating Dupilumab: 3-Year, Real-World, Interim Data from the PROSE Registry. Bhatia N, Lynde CW, Fonacier L, Shao L, Korotzer A, Bosman K.Dermatol Ther (Heidelb). 2025 Apr 15. doi: 10.1007/s13555-025-01395-1. Online ahead of print.PMID: 40234297

 

  1. Primary Technology-Enhanced Care for Hypertension Scaling Program: Trial-Based Economic Evaluation Examining Effectiveness and Cost-Effectiveness Using Real-World Data in Singapore. Wang Y, Tyagi S, Ng DWL, Teo VHY, Kok D, Foo D, Koh GC.J Med Internet Res. 2025 Apr 15;27:e59275. doi: 10.2196/59275.PMID: 40233358 Free article.

 

  1. Bridging Data Silos in Oncology with Modular Software for Federated Analysis on Fast Healthcare Interoperability Resources: Multisite Implementation Study. Ziegler J, Erpenbeck MP, Fuchs T, Saibold A, Volkmer PC, Schmidt G, Eicher J, Pallaoro P, De Souza Falguera R, Aubele F, Hagedorn M, Vansovich E, Raffler J, Ringshandl S, Kerscher A, Maurer JK, Kühnel B, Schenkirsch G, Kampf M, Kapsner LA, Ghanbarian H, Spengler H, Soto-Rey I, Albashiti F, Hellwig D, Ertl M, Fette G, Kraska D, Boeker M, Prokosch HU, Gulden C.J Med Internet Res. 2025 Apr 15;27:e65681. doi: 10.2196/65681.PMID: 40233352 Free article.

 

  1. Real-world treatment patterns and outcomes with oral azacitidine maintenance therapy in patients with acute myeloid leukemia. Leber B, Ruiz MT, Elgendy H, Pettersson F, Prebet T, Vigil CE, Parikh RC, Korgaonkar S, Bello F, Davis KL, Gaugler L, Strocchia M, Sieluk J, Li Y, Schuh AC. 2025 Apr 15;131(8):e35845. doi: 10.1002/cncr.35845.PMID: 40233158

 

  1. Final 3-year results from the EVIDENS study, an observational study of nivolumab in non-small cell lung cancer. Barlesi F, Dixmier A, Debieuvre D, Raspaud C, Auliac JB, Benoit N, Bombaron P, Moro-Sibilot D, Asselain B, Audigier-Valette C, Brellier F, Cotté FE, Khalife Y, Pérol M. 2025 Dec;14(1):2492932. doi: 10.1080/2162402X.2025.2492932. Epub 2025 Apr 15.PMID: 40232811 Free PMC article.

 

  1. Real-world treatment patterns, outcomes, and economic costs by lines of therapy in patients with newly diagnosed multiple myeloma: a nationwide population-based cohort study in South Korea. Park SS, Park Y, Yoon S, Lee D, Jeong J, Kim K.Blood Res. 2025 Apr 15;60(1):26. doi: 10.1007/s44313-025-00069-3.PMID: 40232584 Free PMC article.

 

  1. Clinical Impact and Cost-Effectiveness of Updated 2023/24 COVID-19 mRNA Vaccination in High-Risk Populations in the United States. Joshi K, Dronova M, Paterak E, Nguyen VH, Kopel H, Mansi J, Van de Velde N, Beck E.Infect Dis Ther. 2025 Apr 15. doi: 10.1007/s40121-025-01128-z. Online ahead of print.PMID: 40232338

 

  1. Janus kinase inhibitors show a longer drug survival than biologics in a real-world cohort of patients with rheumatoid arthritis - a retrospective analysis from the RHADAR database. Risser LM, Witte T, Englbrecht M, Strunz PP, Froehlich M, Schmalzing M, Gernert M, Bartz-Bazzanella P, von der Decken C, Karberg K, Gauler G, Späthling-Mestekemper S, Kuhn C, Vorbrüggen W, Welcker M, Kleinert S.Rheumatol Int. 2025 Apr 15;45(5):100. doi: 10.1007/s00296-025-05859-7.PMID: 40232336

 

  1. Machine learning for high-risk hospitalization prediction in outpatient individuals with diabetes at a tertiary hospital. Deina C, Fogliatto FS, Reis MAD, Schaan BD.Arch Endocrinol Metab. 2025 Apr 15;69(2):e230348. doi: 10.20945/2359-4292-2024-0317.PMID: 40232166 Free PMC article.

 

  1. Enhancing risk stratification and treatment decision in multiple myeloma with SKY92 gene expression profiling in real-world data. Biran N, Dhakal B, Niesvizky R, Lentzsch S, Bhutani D, McKay JT, Vesole DH, Nooka A, Paul B, Hari PN, D'Ambrosi S, Kuiper R, van Vliet M, Siegel D, Usmani SZ, van Rhee F.Br J Haematol. 2025 Apr 15. doi: 10.1111/bjh.20050. Online ahead of print.PMID: 40231946

 

  1. Insight Review on Data Quality Management in Pharmacovigilance. Bassi P, Kaur N, Rana S, Kaur A, Malik DS.Curr Drug Saf. 2025 Apr 14. doi: 10.2174/0115748863344567250327085214. Online ahead of print.PMID: 40231501

 

  1. Closed-loop therapy: recent advancements and potential predictors of glycemic outcomes. Royston C, Hovorka R, Boughton CK.Expert Opin Drug Deliv. 2025 Apr 18:1-18. doi: 10.1080/17425247.2025.2492363. Online ahead of print.PMID: 40231429 Review.

 

  1. Semantic and relation aware neural network model for bi-class multi-relational heterogeneous graphs. Zhao Y, Liu H, Duan H. 2025 Mar 7;28(4):112155. doi: 10.1016/j.isci.2025.112155. eCollection 2025 Apr 18.PMID: 40230523 Free PMC article.

 

  1. Deep targeted sequencing of circulating tumor DNA to inform treatment in patients with metastatic castration-resistant prostate cancer. Nørgaard M, Rusan M, Kondrup K, Sørensen EMG, Weiss S, Bjerre MT, Fredsøe J, Vang S, Jensen JB, De Laere B, Grönberg H, Borre M, Lindberg J, Sørensen KD.J Exp Clin Cancer Res. 2025 Apr 14;44(1):120. doi: 10.1186/s13046-025-03356-0.PMID: 40229848 Free PMC article.

 

  1. STREAMLINE - Retrospective Cohort Study of FMS-like Tyrosine Kinase 3-Mutated Acute Myeloid Leukemia: Real-World Treatment Patterns and Clinical Outcomes of Patients in First Relapse or Refractory Diagnosis. Zeidan AM, Yu R, Wang Y, Lan Z, Grinblatt DL, Elsouda D, Spalding J, Block A, Touya M, Walker MS, Pandya BJ.Acta Haematol. 2025 Apr 14:1-20. doi: 10.1159/000545384. Online ahead of print.PMID: 40228486 Free article.

 

  1. Importance of Health Economics and Outcomes Research in the Product Lifecycle. Dang A.Pharmaceut Med. 2025 Apr 14. doi: 10.1007/s40290-025-00564-z. Online ahead of print.PMID: 40227495 Review.

 

  1. Clinical characteristics, treatment patterns and outcomes of patients with follicular lymphoma in Colombia: a real-world evidence cohort study. Enciso L, González FJ, Pérez LE, Ramos AM, Samacá-Samacá D, Badillo C.Ann Hematol. 2025 Apr 14. doi: 10.1007/s00277-025-06341-x. Online ahead of print.PMID: 40227475

 

  1. A nationwide study of primary biliary cholangitis prevalence, geographic distribution, and health care providers. Levy C, Buchanan-Peart KA, MacEwan JP, Levine A, Nair R, Wheeler D, Bessonova L, Goel A, Gish RG, Bonder A.Hepatol Commun. 2025 Apr 14;9(5):e0677. doi: 10.1097/HC9.0000000000000677. eCollection 2025 May 1.PMID: 40227093 Free PMC article.

 

  1. Unveiling the effectiveness and safety spectrum of biologic therapies in psoriasis: a three-year real-world analysis. Demirbas A, Diremsizoglu E, Esen M, Ulutas Demirbas G.Postgrad Med. 2025 Apr 15:1-10. doi: 10.1080/00325481.2025.2493042. Online ahead of print.PMID: 40227059

 

  1. Effectiveness of total hip arthroplasty versus non-surgery on patient-reported hip function at 3 months: a target trial emulation study of patients with osteoarthritis. Klaassen AD, Jorritsma W, Willigenburg NW, Gerritsma CLE, Ten Have BLEF, Moojen DJF, Gademan MGJ, Groenwold RHH, Poolman RW.Acta Orthop. 2025 Apr 14;96:310-316. doi: 10.2340/17453674.2025.43332.PMID: 40223676 Free PMC article.

 

  1. Editorial: Real-World Evidence of Upadacitinib-An Effective Induction Therapy for Crohn's Disease? Authors' Reply. Richard N, Fumery M.Aliment Pharmacol Ther. 2025 Apr 14. doi: 10.1111/apt.70149. Online ahead of print.PMID: 40223527 No abstract available.

 

  1. Editorial: Real-World Evidence of Upadacitinib-An Effective Induction Therapy for Crohn's Disease? Ramos-Belinchon C, Plevris N.Aliment Pharmacol Ther. 2025 Apr 14. doi: 10.1111/apt.70113. Online ahead of print.PMID: 40223506 No abstract available.

 

  1. Leveraging real-world data to advance biomarker discovery and precision oncology. Luo J, Solit DB.Cancer Cell. 2025 Apr 14;43(4):606-610. doi: 10.1016/j.ccell.2025.03.012. Epub 2025 Mar 27.PMID: 40154486 Review.

 

  1. STARTing a new path in cardiovascular prevention: Lessons from SELECT and real-world evidence on Semaglutide in obesity-driven risk. Andò G, Cavolina G, Villari A, Sabouret P, Musumeci G.Int J Cardiol. 2025 Apr 15;425:133058. doi: 10.1016/j.ijcard.2025.133058. Epub 2025 Feb 13.PMID: 39954788 No abstract available.

 

  1. Clinical Efficacy of Ovine Forestomach Matrix and Collagen/Oxidised Regenerated Cellulose for the Treatment of Venous Leg Ulcers: A Retrospective Comparative Real-World Evidence Study. Aburn R, Chaffin AE, Bosque BA, Frampton C, Dempsey SG, Young DA, May BCH, Bohn GA, Melin MM. Int Wound J. 2025 Apr;22(4):e70368. doi: 10.1111/iwj.70368. PMID: 40251820