2025 -  WEEK 11

What's New in RWE Research this Week

  1. A Brief Report on Proposed Areas of International Harmonization of Real-World Evidence Relevance, Reliability and Quality Standards Among Medical Product Regulators. Nafie M, Parker VJ, McClellan M, Hendricks-Sturrup RM. Pharmacoepidemiol Drug Saf. 2025 Mar;34(3):e70127. doi: 10.1002/pds.70127. PMID: 40084391

 

  1. Real-World Data and Real-World Evidence in Regulatory Decision Making: Report Summary From the Council for International Organizations of Medical Sciences (CIOMS) Working Group XIII. Hennessy S, Atsuta Y, Hill S, Rägo L, Juhaeri J; Council for International Organizations of Medical Sciences (CIOMS) Working Group XIII. Pharmacoepidemiol Drug Saf. 2025 Mar;34(3):e70117. doi: 10.1002/pds.70117. PMID: 40070104 Free PMC article.

 

  1. A large-scale benchmark for network inference from single-cell perturbation data. Chevalley M, Roohani YH, Mehrjou A, Leskovec J, Schwab P. Commun Biol. 2025 Mar 11;8(1):412. doi: 10.1038/s42003-025-07764-y. PMID: 40069299 Free PMC article.

 

  1. Implementing Accuracy, Completeness, and Traceability for Data Reliability. Riskin DJ, Monda KL, Gagne JJ, Reynolds R, Garan AR, Dreyer N, Muntner P, Bradbury BD. JAMA Netw Open. 2025 Mar 3;8(3):e250128. doi: 10.1001/jamanetworkopen.2025.0128. PMID: 40063029 Free PMC article.

 

  1. Drug-induced noninfectious myocarditis: a disproportionality analysis of the FAERS database. Yan L, Zheng G. Expert Opin Drug Saf. 2025 Mar;24(3):345-353. doi: 10.1080/14740338.2024.2423679.

 

  1. Ocular adverse events associated with GLP-1 receptor agonists: a real-world study based on the FAERS database and network pharmacology. Luo ZY, Li X, Chen CT, Kang HH, Zhang ZJ, Wang D, Gong JR. Expert Opin Drug Saf. 2025 Mar;24(3):287-296. doi: 10.1080/14740338.2024.2419989.

 

  1. Clinical Outcomes of Extended Venous Thromboembolism Prophylaxis, After Oncologic Colorectal Surgery. Corbin SL, Harris L, Fuccello A, Laryea J, Schootman M, Martin BC, Mavros MN.J Gastrointest Surg. 2025 Mar 12:102018. doi: 10.1016/j.gassur.2025.102018. Online ahead of print.PMID: 40086587

 

  1. Methods for the health technology assessment of complex interventions: A scoping review. Baghbanian A, Carter D, Merlin T.PLoS One. 2025 Mar 14;20(3):e0315381. doi: 10.1371/journal.pone.0315381. eCollection 2025.PMID: 40085544 Review.

 

  1. Postoperative radiotherapy improves long-term survival in HER2-positive metastatic breast cancer: real-worlde vidence from the latest SEER database. Xie LX, Liu Y, Yang YG, Wang JN, Zhang YQ, Wang T, Bian LY, Jiang H, Su XM, Zhou YC. Breast Cancer Res Treat. 2025 Mar 14. doi: 10.1007/s10549-025-07665-y. Online ahead of print.PMID: 40085414

 

  1. The value of real-world evidence in supporting targeted therapies for patients with rare oncogenic drivers in mNSCLC. Nagasaka M, Roy UB, Berk A, Liu G, Nadler E, Abrahami D.Future Oncol. 2025 Mar 14:1-7. doi: 10.1080/14796694.2025.2475728. Online ahead of print.PMID: 40084656

 

  1. Kidney outcomes with SGLT2 inhibitors in patients with diabetes and an insulin-deficient phenotype: A real world analysis. Tsur A, Cahn A, Hanoch L, Pollack R.Diabetes Obes Metab. 2025 Mar 14. doi: 10.1111/dom.16329. Online ahead of print.PMID: 40084557

 

  1. Assessing the economic burden of Waldenström's Macroglobulinemia (WM), Marginal Zone Lymphoma (MZL), and Chronic Lymphocytic Leukemia (CLL). Scortichini M, Paoletti M, Ragonese A, Cuneo A, Vignetti M, Zinzani PL.Glob Reg Health Technol Assess. 2025 Mar 11;12:80-88. doi: 10.33393/grhta.2025.3365. eCollection 2025 Jan-Dec.PMID: 40083541 Free PMC article.

 

  1. Accelerating precision oncology by converging pragmatic trials and real-world evidence. Taskén K, Mahon P.Nat Rev Drug Discov. 2025 Mar 13. doi: 10.1038/d41573-025-00047-5. Online ahead of print.PMID: 40082591 No abstract available.

 

  1. Real-world treatment patterns and outcomes based on RAS/BRAF status in metastatic colorectal cancer-Analysis of the Prospective Dutch Colorectal Cancer cohort. van Nassau SCMW, Zwart K, van der Baan FH, Vink GR, Elferink MAG, Snaebjornsson P, May AM, Koopman M, Roodhart JML.Int J Cancer. 2025 Mar 13. doi: 10.1002/ijc.35410. Online ahead of print.PMID: 40081858

 

  1. Prognostic significance of pre-treatment immune-inflammation biomarkers in anal cancer: A study combining real-worlddata and a meta-analysis. Wind KL, Steffensen JH, Jakobsen AV, Kronborg C, Spindler KG.Int J Cancer. 2025 Mar 13. doi: 10.1002/ijc.35404. Online ahead of print.PMID: 40081837

 

  1. Incidence of Conjunctivitis and Keratitis Among Individuals with Moderate-to-Severe Atopic Dermatitis Treated with Dupilumab in the United States: a Cohort Study in Routine Care Based on Healthcare Claims. Franklin JM, Marcus AF, Sultan I, Howell A, Sinnott SJ, Green J, Ezzy S, Gately R, Sobel RE, Wang FT.Dermatol Ther (Heidelb). 2025 Mar 13. doi: 10.1007/s13555-025-01367-5. Online ahead of print.PMID: 40080322

 

  1. High Systemic Disease Risk and Therapeutic Delays in Plaque Psoriasis: A Retrospective Analysis of Apremilast Use in the British Association of Dermatologists Biologic and Immunomodulators Register (BADBIR). Shams K, Montgomery J, Morley J, Gerasimaviciute V, Seesaghur A, Neasham D, Tran KV, Cordey M, Taylor A. Dermatol Ther (Heidelb). 2025 Mar 13. doi: 10.1007/s13555-025-01358-6. Online ahead of print.PMID: 40080321

 

  1. Harnessing Generative AI in Exercise and Sports Science Education: Enhancing Real-World Learning and Overcoming Traditional Barriers in Data Analysis. Fazackerley LA, Perrin D, Minett GM. Adv Physiol Educ. 2025 Mar 13. doi: 10.1152/advan.00249.2024. Online ahead of print.PMID: 40080119

 

  1. Long-Term Follow-Up of the S-ICD: A 10-Years Follow-Up Study of a Large Single Center Cohort. Frommeyer G, Reinke F, Rath B, Wolfes J, Willy K, Wegner FK, Köbe J, Eckardt L.Pacing Clin Electrophysiol. 2025 Mar 13. doi: 10.1111/pace.15173. Online ahead of print.PMID: 40080057

 

  1. Challenges and Possible Strategies to Address Them in Rare Disease Drug Development: A Statistical Perspective. Chen J, Nie L, Lee S, Chu H, Tian H, Wang Y, He W, Jemielita T, Gruber S, Song Y, Tamura R, Tian L, Zhao Y, Chen Y, van der Laan M, Lee H.Clin Pharmacol Ther. 2025 Mar 13. doi: 10.1002/cpt.3631. Online ahead of print.PMID: 40079686 Review.

 

  1. Clinical outcomes and molecular characteristics of lung-only and liver-only metastatic pancreatic cancer: results from a real-world evidence Levi A, Blais E, Davelaar J, Ebia MI, Minasyan A, Nikravesh N, Gresham G, Zheng L, Chuy JW, Shroff RT, Wadlow RC, DeArbeloa P, Matrisian LM, Petricoin E, Pishvaian MJ, Gong J, Hendifar AE, Osipov A.Oncologist. 2025 Mar 10;30(3):oyaf007. doi: 10.1093/oncolo/oyaf007.PMID: 40079530 Free PMC article.

 

  1. Harnessing Electronic Health Records and Artificial Intelligence for Enhanced Cardiovascular Risk Prediction: A Comprehensive Review. Tsai ML, Chen KF, Chen PC.J Am Heart Assoc. 2025 Mar 13:e036946. doi: 10.1161/JAHA.124.036946. Online ahead of print.PMID: 40079336 Free article.

 

  1. Effectiveness and Safety of Tralokinumab in Atopic Dermatitis: 1-year Results From a Real-world Multicentre Study. Calabrese L, Cinotti E, D'Onghia M, Cartocci A, Rubegni P, Maccari F, Boulard C, Reguiai Z, Becherel PA, Jacobzone C, Begon E, Fite C, Walls B, Liegeon AL, Parier J, Chaby G, Perrot JL; Omcci Group.Acta Derm Venereol. 2025 Mar 12;105:adv42275. doi: 10.2340/actadv.v105.42275.PMID: 40077977 Free article.

 

  1. Belimumab patient profile in Spain: evolution during the last decade and future directions. Salman-Monte TC, Cuadrado MJ, Galindo M, Espinosa G, Morales E, Pego-Reigosa JM, Pallarés L, López C, San Román C, Rúa-Figueroa Í.Expert Opin Biol Ther. 2025 Mar 12. doi: 10.1080/14712598.2025.2479018. Online ahead of print.PMID: 40077897 Review.

 

  1. A cohort study of prolactin and non-puerperal mastitis using real world data. Yin Y, Le H, Cheng Y, Zhong Y, Cheng Y, Wang B, Wu J, Ye M, Chen H.Sci Rep. 2025 Mar 12;15(1):8619. doi: 10.1038/s41598-025-92504-9.PMID: 40075120 Free PMC article.

 

  1. Dual antiplatelet pre-treatment with aspirin and ticagrelor in ACS patients undergoing unplanned aortocoronary bypass surgery. Salbach C, Yildirim M, Gulba R, Milles BR, Biener M, Mueller-Hennessen M, Hund H, Frey N, Giannitsis E.Clin Res Cardiol. 2025 Mar 12. doi: 10.1007/s00392-025-02629-0. Online ahead of print.PMID: 40074926

 

  1. LDL cholesterol levels and treatment intensity in secondary prevention of patients with ischemic heart disease in the primary care setting: a real-world data registry study. Sánchez-Ruano N, Fibla-Matamoros A, Falces C, Sánchez E, Sisó-Almirall A, González de Paz L. BJGP Open. 2025 Mar 12:BJGPO.2024.0220. doi: 10.3399/BJGPO.2024.0220. Online ahead of print.PMID: 40074282

 

  1. Worldwide Innovative Network (WIN) Consortium in Personalized Cancer Medicine: Bringing next-generation precision oncology to patients. El-Deiry WS, Bresson C, Wunder F, Carneiro BA, Dizon DS, Warner JL, Graff SL, Azzoli CG, Wong ET, Cheng L, Mani SA, Safran HP, Williams C, Meissner T, Solomon B, Rubin E, Porgador A, Berchem G, Saintigny P, Onn A, Bar J, Berger R, Gantenbein M, Chen Z, Souza CP, Reis RMV, Sekacheva M, Cervantes A, Dahut WL, Annunziata CM, Gober K, Musallam KM, Al-Shamsi HO, Abu-Gheida I, Salazar R, Limaye S, Aref AT, Reddel RR, Homsi MUA, Rouf A, Dermime S, Suwaidi JA, Vlad C, Buiga R, Omari AA, Abdel-Razeq H, Oñate-Ocaña LF, Nielsen FC, Graham L, Rueter J, Joshua AM, Girda E, Libutti S, Riedlinger G, Salem ME, Farhangfar CJ, Mesa RA, Faltas BM, Elemento O, Pramesh CS, Sengar M, Aoyama S, Ikeda S, Berindan-Neagoe I, Gaddipati H, Kulkarni M, Auzias E, Gerogianni M, Wolikow N, Istolainen S, Schlafrig P, Frankel NZ, Ferraro AR, Palma J, Gimenez AP, Hernando-Calvo A, Felip E, Tsimberidou AM, Herbst RS, Tabernero J, Schilsky RL, Liu J, Lussier Y, Raynaud J, Batist G, Magidi S, Kurzrock R. 2025 Mar 12;16:140-162. doi: 10.18632/oncotarget.28703.PMID: 40073368 Free article.Review.

 

  1. Naldemedine Use and Healthcare Resource Utilization in Patients treated with Opioid Analgesics for Chronic Non-Cancer Pain: Results of a Real-world Study in the USA. De Vincentis A, Cai B, Moscarda M, Barnes PMF, Antonelli Incalzi R.Pain Ther. 2025 Mar 12. doi: 10.1007/s40122-025-00720-y. Online ahead of print.PMID: 40072725

 

  1. Burden of mild and moderate atopic dermatitis in adults: results from a real-world study in the United States. Silverberg JI, Anderson P, Cappelleri JC, Piercy J, Levenberg ME, Myers DE, Gerber RA.Arch Dermatol Res. 2025 Mar 12;317(1):556. doi: 10.1007/s00403-025-03910-y.PMID: 40072609 Free PMC article.

 

  1. Performance of an Automated Insulin Delivery System in People Living With Type 2 Diabetes and Insulin Resistance: First Real-World Evidence in 26 427 Users. Thijs I, Arrieta A, Castañeda J, Joubert M, Giorgino F, Voelker B, Van den Heuvel T, Basset-Sagarminaga J, Petrovski G, Shin J, Vigersky R, Cohen O.J Diabetes Sci Technol. 2025 Mar 12:19322968251318373. doi: 10.1177/19322968251318373. Online ahead of print.PMID: 40071717

 

  1. Post-market safety profile of cefiderocol: a real-world pharmacovigilance exploratory analysis based on U.S. FDA adverse event reporting system (FAERS). Lin H, Zhu C, Liu S, Bi Y, Hu J, Ju M.BMC Pharmacol Toxicol. 2025 Mar 11;26(1):58. doi: 10.1186/s40360-025-00894-3.PMID: 40069825 Free PMC article.

 

  1. Patient-reported therapeutic benefits of herbal medicinal products in the treatment of gynecological ailments. Drebka A, Scholl AJ, Ochs T, Kelber O, Mösges R, Raskopf E, Shah-Hosseini K, Bachmeier BE.BMC Complement Med Ther. 2025 Mar 11;25(1):99. doi: 10.1186/s12906-025-04761-w.PMID: 40069740 Free PMC article.

 

  1. Efficacy and continuability of 675 mg fremanezumab administration over 2 years. Yoshida S, Imai N, Keicho M, Kamimura J, Moriya A, Yagi N, Suzuki R, Konishi T, Serizawa M.J Headache Pain. 2025 Mar 11;26(1):51. doi: 10.1186/s10194-025-01994-5.PMID: 40069630 Free PMC article.

 

  1. Real world evidence for altered communication patterns in individuals with autism spectrum disorder. Turna M, Eckert J, Meier-Böke K, Narava M, Chaliani I, Eickhoff SB, Schilbach L, Dukart J.NPJ Digit Med. 2025 Mar 11;8(1):155. doi: 10.1038/s41746-025-01545-x.PMID: 40069447 Free PMC article.

 

  1. Second booster doses of adenoviral- and mRNA-based COVID-19 vaccines increase protection against COVID-19 hospitalization: Final analysis from the REFORCO-Brazil real-world effectiveness study during Omicron. Meeraus W, Postema A, Gray CM, Lee A, Maria AS, Furtado BE, Conde-Sousa E, Ouwens M, Valverde DA, da Cunha CA, Barbosa AN, Corte C, Taylor S. 2025 Mar 10;53:126955. doi: 10.1016/j.vaccine.2025.126955. Online ahead of print.PMID: 40068393

 

  1. Assessing the Data Quality Dimensions of Partial and Complete Mastectomy Cohorts in the All of UsResearch Program: Cross-Sectional Study. Spotnitz M, Giannini J, Ostchega Y, Goff SL, Anandan LP, Clark E, Litwin TR, Berman L.JMIR Cancer. 2025 Mar 11;11:e59298. doi: 10.2196/59298.PMID: 40068169

 

  1. Impact of alternating electric fields therapy for newly diagnosed WHO grade 4 astrocytoma on patient survival: a real-world propensity-score adjusted prospective multicenter study. Woo PYM, Pu JKS, Li LF, Wong DKK, Hui VKH, Chan DTM, Lee MWY, Chan TKT, Ho JMK, Cheung KM, Tse TPK, Lau SSN, Chow JSW, Ko NMW, Loong HHF, El-Helali A, Lam TC, Cheung FC, Poon WS.J Neurooncol. 2025 Mar 11. doi: 10.1007/s11060-025-04985-3. Online ahead of print.PMID: 40067514

 

  1. A Benchmark, Expand, and Calibration (BenchExCal) Trial Emulation Approach for Using Real-World Evidence to Support Indication Expansions: Design and Process for a Planned Empirical Evaluation. Wang SV, Russo M, Glynn RJ, Bradley MC, He J, Concato J, Schneeweiss S. Clin Pharmacol Ther. 2025 Mar 11. doi: 10.1002/cpt.3621. Online ahead of print.PMID: 40067205

 

  1. The burden of migraine in Mexico: a database analysis of migraine-related visits to emergency departments in Mexico's ministry of health (MMoH) hospitals. Sanchez Trujillo LA, Pastrana ME, Galnares Olalde JA, Marfil A, Partida Medina LR, Gudiño Castelazo M, Osorio-Hernandez M, Caballero N, Julian GS.Expert Rev Neurother. 2025 Mar 11. doi: 10.1080/14737175.2025.2474557. Online ahead of print.PMID: 40067171 Free article.

 

  1. Integrated Evidence Planning for Enhancing Patient Care: Harnessing the Power of Real-World Evidence. Capkun G, Olson MS.Clin Pharmacol Ther. 2025 Mar 11. doi: 10.1002/cpt.3632. Online ahead of print.PMID: 40066671

 

  1. Effectiveness of phosphate binders on mortality and cardiovascular disease in end-stage renal disease patients with hyperphosphatemia: a multicenter real-world cohort study. Chaiyakittisopon K, Pattanaprateep O, Ponthongmak W, Kunakorntham P, Chuasuwan A, Ingsathit A, Mckay GJ, Attia J, Thakkinstian A.BMC Nephrol. 2025 Mar 10;26(1):131. doi: 10.1186/s12882-025-04058-7.PMID: 40065267 Free PMC article.

 

  1. 3D volumetric tomography of clouds using machine learning for climate analysis. Ronen R, Koren I, Levis A, Eytan E, Holodovsky V, Schechner YY.Sci Rep. 2025 Mar 10;15(1):8270. doi: 10.1038/s41598-025-90169-y.PMID: 40064962 Free PMC article.

 

  1. Abrocitinib as a novel therapeutic approach for refractory prurigo nodularis: real-world evidence. Demirbas A, Diremsizoglu E, Cınar G, Vural C.Arch Dermatol Res. 2025 Mar 11;317(1):543. doi: 10.1007/s00403-025-04071-8.PMID: 40064674 No abstract available.

 

  1. Cardiac implantable electronic device carriers undergoing transcatheter tricuspid valve annuloplasty: real-world insights. Wrobel JM, Kirchner J, Friedrichs K, Gietzen T, Althoff J, Hasse C, von Stein P, Wörmann J, von Stein J, Curio J, Rudolph F, Ivannikova M, Iliadis C, Steven D, Baldus S, Rudolph V, Pfister R, Gerçek M, Koerber MI.Clin Res Cardiol. 2025 Mar 10. doi: 10.1007/s00392-025-02616-5. Online ahead of print.PMID: 40063122

 

  1. Selective serotonin reuptake inhibitors (SSRIs) and osteoporosis: A target trial emulation using real-world data. Rohde C, Williams LJ, Berk M, Østergaard SD.Acta Neuropsychiatr. 2025 Mar 10:1-23. doi: 10.1017/neu.2025.3. Online ahead of print.PMID: 40062740

 

  1. Innovative Real-World Data Use for Identifying Stroke Survivors and Access to Rehabilitation in Primary Care in Brazil. Machline-Carrion MJ, Girotto AN, Nieri J, Pereira PM, Cuperman-Poll T, Serafini P. 2025 Mar 10. doi: 10.1161/STROKEAHA.124.046946. Online ahead of print.PMID: 40062401

 

  1. Efficacy and Safety of Lung Volume Reduction with Endobronchial Coil #2 and Coil #4 Results of the German Emphysema Registry-Lungenemphysemregister e.V. Grah C, Oei SL, Krist J, Wiesemann B, Schmidt B, Fertl A, Schwick B, Hübner RH, Becke B, Franke KJ, Geltner C, Eisenmann S, Stanzel F, Barten-Neiner G, Sgarbossa T, Blazejczyk K, Wüstefeld H. 2025 Dec;22(1):2468328. doi: 10.1080/15412555.2025.2468328. Epub 2025 Mar 10.PMID: 40059773 Free article.

 

  1. Long-term clinical outcomes of dienogest for perimenopausal women with symptomatic adenomyosis. Chen CH, Lin YH, Lee CY, Shen H, Hsu YT, Wu PC.Sci Rep. 2025 Mar 10;15(1):8174. doi: 10.1038/s41598-025-93156-5.PMID: 40059225 Free PMC article.

 

  1. What can real-world data teach us about treating patients with unresectable hepatocellular carcinoma? Dalbeni A, Cattazzo F, Natola LA, Zoncapè M, Faccincani D, Stefanini B, Ravaioli F, Villani R, Auriemma A, Sacerdoti D.Expert Rev Gastroenterol Hepatol. 2025 Mar 10:1-10. doi: 10.1080/17474124.2025.2476541. Online ahead of print.PMID: 40042586 Review.

 

  1. Reproduction of Original Glioblastoma and Brain Metastasis Research Findings Using Synthetic Data. Davalan W, Khalaf R, Diaz RJ. World Neurosurg. 2025 Mar 13;196:123808. doi: 10.1016/j.wneu.2025.123808. Online ahead of print.PMID: 39983991

 

  1. Cost-effectiveness of treatment sequences for BRAF-mutant advanced melanoma in the Netherlands using a health economic model. Blommestein HM, de Groot S, Leeneman B, Uyl-de Groot CA, Haanen JBAG, Wouters MWJM, Aarts MJB, van den Berkmortel FWPJ, Blokx WAM, Boers-Sonderen MJ, van den Eertwegh AJM, de Groot JWB, Hospers GAP, Kapiteijn E, van Not OJ, van der Veldt AAM, Suijkerbuijk KPM, Franken MG.Eur J Cancer. 2025 Mar 11;218:115071. doi: 10.1016/j.ejca.2024.115071. Epub 2024 Oct 16.PMID: 39914026

 

  1. Prevalence and Clinical Outcomes of Discordant Lesions Between Fractional Flow Reserve and Nonhyperemic Pressure Ratios in Clinical Practice: The J-PRIDE Registry. Kuramitsu S, Kawase Y, Shinozaki T, Domei T, Yamanaka F, Kaneko U, Kakuta T, Horie K, Terai H, Ando H, Shiono Y, Tagashira T, Nogi K, Kubo T, Asano T, Shiraishi J, Otake H, Sugano A, Anai R, Iwai A, Kikuta Y, Nishina H, Fujita T, Amano T, Iwabuchi M, Yokoi H, Akasaka T, Matsuo H, Tanaka N; J-PRIDE Investigators. 2025 Mar 11;151(10):672-685. doi: 10.1161/CIRCULATIONAHA.124.071139. Epub 2025 Jan 9.PMID: 39781739

 

  1. Management of dyslipidaemia in patients with comorbidities-facing the challenge. Frühwald L, Fasching P, Dobrev D, Kaski JC, Borghi C, Wassmann S, Huber K, Semb AG, Agewall S, Drexel H.Eur Heart J Cardiovasc Pharmacother. 2025 Mar 13;11(2):164-173. doi: 10.1093/ehjcvp/pvae095.PMID: 39719399 Review.

 

  1. Treatment patterns and outcomes in follicular lymphoma with POD24: an analysis from the LEO Consortium. Day JR, Larson MC, Durani U, Koff JL, Wang Y, Habermann TM, Lossos IS, Nastoupil LJ, Strouse C, Chihara D, Martin P, Leonard JP, Cohen JB, Kahl BS, Ruan J, Burack WR, Friedberg JW, Cerhan JR, Flowers CR, Link BK, Maurer MJ, Casulo C.Blood Adv. 2025 Mar 11;9(5):1013-1023. doi: 10.1182/bloodadvances.2024014053.PMID: 39602301