📌 Flatiron Health Database, Oncology - Unites States 🇺🇸

🔍 What is it?

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The Flatiron Health Database is a leading oncology-focused real-world data (RWD) source derived from electronic health records (EHRs) of patients receiving cancer care in the United States. Maintained by Flatiron Health, a subsidiary of Roche, this database aggregates structured and unstructured data from a network of community oncology clinics and academic medical centers, supporting oncology research, outcomes analysis, and regulatory decision-making.

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📊 Key Features & Scope

📍 Geographical coverage: United States 🇺🇸

🏥 Data type: Oncology-specific EHRs, including structured (labs, medications) and curated unstructured data (clinician notes, pathology reports)

🕒 Time coverage: Data available since 2014, with ongoing updates

👥 Population covered: 3 million+ active cancer patients across 280+ community clinics and academic centers

🔄 Longitudinal data: Rich patient histories, including treatment sequences, clinical outcomes, and disease progression

📈 Tumor types covered: Broad coverage across solid and hematologic malignancies, with detailed biomarker and treatment data

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✅ Strengths & Best Use Cases

🌍 Diverse oncology population – Represents real-world cancer care across community and academic settings

💊 Treatment patterns & outcomes – Enables studies on medication use, sequencing, and effectiveness in clinical practice

🧬 Biomarker-driven insights – Integrates genomic and molecular testing data

🚀 Regulatory-grade RWD – Used in FDA submissions and external control arms for clinical trials

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⚠️ Limitations & Considerations

🏥 Limited non-oncology data – Primarily focused on oncology patients, with minimal non-cancer-related medical history

📉 EHR-driven variability – Data completeness depends on clinic documentation practices

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📚 How to Access & Learn More

🔗 Access: Requires a research collaboration with Flatiron Health

🎓 Publications: Flatiron Research 

📄 More info: Flatiron Health